Comparison of mid-term clinical outcome in heart transplantation patients using mycophenolate mofetil vs. enteric-coated mycophenolate sodium.

Author: ChoHyun Jai, ChoYang Hyun, ChoiDong-Ju, ChoiJin-Oh, JeonEun-Seok, JeonKina, JungSung-Ho, KangSeok-Min, KimDarae, KimJae-Joong, LeeHae-Young, OhJaewon, ParkJin Joo, SungKiick

Paper Details 
Original Abstract of the Article :
Mycophenolate mofetil (MMF) is a prodrug of mycophenolic acid (MPA) and a key immunosuppressant for improving graft survival in patients with heart transplantation (HTx). However, dose reduction or interruption is occasionally needed due to gastrointestinal (GI) side effects. Enteric-coated mycophen...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448250/

データ提供:米国国立医学図書館(NLM)

Choosing the Right Immunosuppressant for Heart Transplant Patients

Imagine navigating a vast, sun-baked desert, where each oasis represents a different treatment option. This research explores the options for immunosuppressants for heart transplant patients, a group that relies on these medications to prevent rejection of their new organ.

Mycophenolate Mofetil vs. Enteric-Coated Mycophenolate Sodium

This study compares two forms of mycophenolic acid (MPA), a potent immunosuppressant: mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS). Both drugs have the same goal: to suppress the immune system to prevent rejection of the transplanted heart. However, MMF can cause gastrointestinal side effects, which can be a real burden for patients.

Improving Tolerability and Efficacy

The researchers were interested in whether EC-MPS, with its enteric coating, could improve GI tolerability compared to MMF. They found that EC-MPS appeared to be a viable alternative to MMF in heart transplant patients, offering similar efficacy while potentially reducing side effects.

Dr. Camel's Conclusion

The research highlights the importance of finding the right immunosuppressant for each patient, like finding the perfect oasis in a vast desert. This study offers a potential solution for patients who experience GI side effects from MMF, providing hope for a more comfortable and effective treatment journey.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-09-12
Further Info :

Pubmed ID

36082128

DOI: Digital Object Identifier

PMC9448250

Related Literature

SNS
PICO Info
in preparation
Languages

English

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