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A comparison of the effects of timolol and epinephrine on intraocular pressure.

Author: HargettN A, KohnA N, MossA P, PodosS M, RitchR, SmithH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Timolol maleate was more effective than epinephrine hydrochloride in reducing intraocular pressure in patients with glaucoma. Timolol was also associated with fewer side effects.
Paper Details　
Original Abstract of the Article :
We conducted a double-masked, six-week crossover study comparing bilateral twice-a-day therapy with timolol maleate (0.1%, 0.25%, and 0.5%) and epinephrine hydrochloride (0.5%, 1.0%, 2.0%) in 36 otherwise untreated patients. Increasing concentrations of each drug were administered until an arbitrary...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9394(78)90294-5

データ提供：米国国立医学図書館（NLM）

Timolol and Epinephrine: A Balancing Act in Glaucoma Treatment

Glaucoma, like a persistent desert sandstorm, can gradually erode vision, leading to irreversible blindness. This study compares the effects of timolol and epinephrine, two commonly used medications to lower intraocular pressure, providing insights into the unique characteristics of each drug.

Timolol and Epinephrine: A Comparative Analysis

The study reveals that timolol, like a consistent desert wind, effectively lowers intraocular pressure, while epinephrine, like a sudden desert storm, can be more variable in its effects. The researchers found that timolol was generally better tolerated than epinephrine, suggesting that timolol may be a more reliable and safer option for managing glaucoma. The findings provide valuable insights into the distinct properties of these two drugs, helping clinicians make informed treatment decisions.

Navigating the Desert of Glaucoma

This study helps us understand the nuances of treating glaucoma, a disease that can feel like a persistent desert sandstorm. The findings offer a clearer picture of the distinct characteristics of timolol and epinephrine, providing valuable information for clinicians as they navigate the complex landscape of glaucoma treatment.

Dr.Camel's Conclusion

The study highlights the importance of understanding the unique characteristics of different glaucoma medications. It's like navigating a desert landscape, where each terrain requires a different approach to ensure a safe and successful journey.
Date :
  1. Date Completed 1978-12-27
  2. Date Revised 2019-06-27
Further Info :

Pubmed ID

360846

DOI: Digital Object Identifier

10.1016/0002-9394(78)90294-5

Related Literature

Article Analysis
・Effects of timolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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