Incidence, Risk Factors, and Consequences of Human Alphaherpesvirus Infections in Patients With Psoriasis Who Initiate Methotrexate or Biologic Agents.

Author: AjgeiyKawa Khaled, EgebergAlexander, HarboeZitta Barrella, LiljendahlMie Sylow, LoftNikolai, MøllerDina Leth, NielsenSusanne Dam, RasmussenMads Kirchheiner, RezahosseiniOmid, SkovLone

Paper Details 
Original Abstract of the Article :
BACKGROUND: Immunosuppressive agents may increase the risk of infections with human alphaherpesviruses. METHODS: We included all adult patients with moderate to severe psoriasis who initiated methotrexate (MTX) or biologic agents in a retrospective cohort study. An episode of alphaherpesviruses inf...See full text at original site
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引用元:
https://doi.org/10.1093/infdis/jiac367

データ提供:米国国立医学図書館(NLM)

Herpesvirus Infections in Psoriasis Patients: A Closer Look

Psoriasis is a chronic skin condition that affects millions of people. While it can be effectively managed with medications, certain treatments, like methotrexate and biologic agents, can suppress the immune system and increase the risk of infections. This research, published in JAMA Dermatology, focused on the incidence, risk factors, and consequences of alphaherpesvirus infections in psoriasis patients receiving these treatments. It found that the incidence of alphaherpesvirus infection was comparable between those receiving methotrexate and TNF-α inhibitors, while those taking IL-17 inhibitors had a lower risk of infection. The study also investigated the impact of these infections, finding that hospital contacts were more frequent in those on methotrexate and TNF-α inhibitors compared to those taking IL-12/23 or IL-17 inhibitors.

Navigating the Shifting Sands: A Deeper Understanding of Psoriasis Treatment

This research provides valuable insights into the potential risks associated with different treatment options for psoriasis. The authors highlight the importance of monitoring for infections, especially in patients receiving immunosuppressive therapy. These findings, like the changing sands of the desert, offer a dynamic perspective on the complexities of psoriasis treatment, emphasizing the need for careful monitoring and personalized care.

Keeping the Oasis in Sight: Practical Advice for Psoriasis Patients

This study underscores the importance of understanding the potential risks and benefits of different psoriasis treatments. Patients should discuss these risks with their healthcare providers, ensuring that they have access to the information needed to make informed decisions about their care. By understanding the nuances of treatment options, patients can work with their healthcare providers to navigate the complexities of psoriasis management, keeping their health and well-being at the forefront.

Dr. Camel's Conclusion

This research is a reminder that the journey of managing psoriasis, like traversing the desert, can present challenges and surprises. By understanding the potential risks and benefits of treatment options, patients can work with their healthcare providers to navigate this terrain safely and effectively, keeping their health and well-being at the forefront.
Date :
  1. Date Completed 2022-11-03
  2. Date Revised 2022-12-04
Further Info :

Pubmed ID

36097341

DOI: Digital Object Identifier

10.1093/infdis/jiac367

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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