Paper Details

  1. Home
  2. Paper Details

Pitavastatin and Ivermectin Enhance the Efficacy of Paclitaxel in Chemoresistant High-Grade Serous Carcinoma.

Author: DuarteDiana, NunesMariana, RicardoSara, ValeNuno

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explored the synergistic cytotoxic effects of Paclitaxel combined with repurposed drugs in chemoresistant high-grade serous carcinoma cell lines. The findings suggest that Pitavastatin and Ivermectin could be promising drug combinations for high-grade serous carcinoma management.
Paper Details　
Original Abstract of the Article :
Chemotherapy is a hallmark in high-grade serous carcinoma management; however, chemoresistance and side effects lead to therapeutic interruption. Combining repurposed drugs with chemotherapy has the potential to improve antineoplastic efficacy, since drugs can have independent mechanisms of action a...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496819/

データ提供：米国国立医学図書館（NLM）

Pitavastatin and Ivermectin Enhance the Efficacy of Paclitaxel in Chemoresistant High-Grade Serous Carcinoma

This research explores new approaches to treating a type of aggressive ovarian cancer called high-grade serous carcinoma. It's like venturing into a hostile desert, where researchers are searching for ways to combat a relentless enemy. The researchers are investigating the potential of repurposing existing drugs to enhance the effectiveness of chemotherapy.

Combating Chemoresistance in Ovarian Cancer

The researchers found that combining paclitaxel, a commonly used chemotherapy drug, with pitavastatin or ivermectin, drugs typically used for different purposes, significantly enhanced the effectiveness of the treatment. This is like finding a new weapon in the desert, giving researchers a powerful tool to fight against chemoresistance.

Importance of Repurposing Drugs for Cancer Treatment

This research highlights the potential of repurposing existing drugs for cancer treatment. It's like discovering a new oasis in the desert, offering a novel and potentially more effective approach to fighting cancer.

Dr.Camel's Conclusion

This research provides promising new leads for treating chemoresistant ovarian cancer, offering a glimmer of hope for patients battling this aggressive disease. It's a journey of innovation, driven by the relentless pursuit of new solutions for challenging health problems.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-09-28
Further Info :

Pubmed ID

36139522

DOI: Digital Object Identifier

PMC9496819

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.