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Safety and efficacy of pharmacotherapy containing INSTIs and chemotherapy drugs in people living with HIV and concomitant colorectal cancer.

Author: ChenTingyu, GuiFuqiang, TanJuan, WeiGuo, YangJing, ZhaoYong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study reviewed previous clinical data on raltegravir-based antiretroviral therapy (ART) in patients with HIV infection who need cancer chemotherapy and highlighted the need for further research on other integrase inhibitors (INSTIs) in this patient population.
Paper Details　
Original Abstract of the Article :
Previous clinical data have shown that raltegravir-based antiretroviral therapy (ART) with fewer drug-drug interactions (DDIs) and adverse events (AEs) is a good regimen in patients with HIV infection who need cancer chemotherapy. There are currently few data on ART regimens that include Integrase i...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508721/

データ提供：米国国立医学図書館（NLM）

Balancing HIV Treatment and Cancer Therapy

The management of HIV infection and concomitant colorectal cancer presents a complex challenge for healthcare providers. This study focuses on the safety and efficacy of pharmacotherapy containing integrase inhibitors (INSTIs) and chemotherapy drugs in individuals living with HIV and colorectal cancer. The researchers aim to evaluate the effectiveness of ART regimens that include INSTIs, particularly those with fewer drug-drug interactions (DDIs) and adverse events (AEs), in this patient population.

Navigating the Complexities of Combined Treatment

The study acknowledges that there is limited data on the use of ART regimens including INSTIs other than RAL in patients with HIV and concomitant colorectal cancer. This research seeks to expand the understanding of these treatment options, potentially leading to improved management strategies for this unique patient population.

Balancing Safety and Efficacy in Complex Medical Conditions

This study emphasizes the importance of balancing safety and efficacy when treating patients with complex medical conditions. The researchers are carefully examining the potential risks and benefits of various treatment regimens, aiming to find the most appropriate approach for each individual. This research represents a crucial step towards optimizing treatment for individuals living with both HIV and colorectal cancer, offering a path towards improved quality of life and potentially extended survival.

Dr. Camel's Conclusion

This study highlights the challenges and complexities of treating individuals living with HIV and concomitant colorectal cancer. The research seeks to provide valuable insights into the safety and efficacy of pharmacotherapy containing INSTIs and chemotherapy drugs, aiming to improve treatment outcomes for this patient population. This is a testament to the ongoing efforts of researchers to find innovative and effective solutions for complex medical conditions, striving to improve the lives of patients facing multiple health challenges.

Date :
  1. Date Completed 2022-09-28
  2. Date Revised 2022-12-10
Further Info :

Pubmed ID

36151562

DOI: Digital Object Identifier

PMC9508721

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English

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