Paper Details

  1. Home
  2. Paper Details

Effects of voriconazole and fluconazole on the pharmacokinetics of almonertinib in rats by UPLC-MS/MS.

Author: CuiYanjun, DongZhanjun, FanLiju, FuYuhao, HeXueru, LiYing, MaYinling, XunXuejiao

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A new method for measuring almonertinib, a drug used for lung cancer, in plasma was developed and validated. This method can be used to study the pharmacokinetic effects of almonertinib and potential interactions with other drugs, such as voriconazole and fluconazole.
Paper Details　
Original Abstract of the Article :
Almonertinib was included in the first-line treatment of non-small cell lung cancer with EGFR T790M mutations by the Chinese Society of Clinical Oncology in 2021. Considering that immunocompromised lung cancer patients are prone to opportunistic fungal infections, and most triazole antifungal drugs ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1002/bmc.5525

データ提供：米国国立医学図書館（NLM）

Almonertinib: A Desert Oasis for EGFR T790M Lung Cancer

This research explores the complex terrain of non-small cell lung cancer, focusing on the use of almonertinib, a targeted therapy for patients with EGFR T790M mutations. The study investigates the potential for drug interactions between almonertinib and commonly used antifungal medications, voriconazole and fluconazole. The findings reveal that these antifungal drugs can significantly alter the pharmacokinetics of almonertinib, potentially impacting its effectiveness and safety.

Navigating the Desert of Drug Interactions

The study found that voriconazole and fluconazole significantly increased the systemic exposure of almonertinib in rats, suggesting a potential for drug interactions that could alter the drug's efficacy and safety. This is like encountering a shifting sand dune in the desert, altering the landscape and potentially impacting the journey ahead. The findings highlight the importance of considering potential drug interactions when prescribing almonertinib, particularly for patients receiving antifungal therapy.

A Balancing Act: Prescribing Almonertinib and Antifungal Medications

The study emphasizes the need for careful monitoring and dose adjustments when prescribing almonertinib in conjunction with antifungal medications. This is like navigating a narrow path in the desert, carefully considering the risks and rewards of each step. The findings underscore the importance of a collaborative approach between oncologists and pharmacists to optimize patient care and ensure safe and effective treatment.

Dr.Camel's Conclusion

This study highlights the importance of considering potential drug interactions when prescribing almonertinib, a targeted therapy for EGFR T790M lung cancer. The findings suggest that commonly used antifungal medications, voriconazole and fluconazole, can significantly alter the pharmacokinetics of almonertinib, potentially impacting its effectiveness and safety. This research emphasizes the need for careful monitoring and dose adjustments when prescribing almonertinib in conjunction with antifungal medications, promoting a collaborative approach to patient care and ensuring optimal treatment outcomes.
Date :
  1. Date Completed 2022-12-16
  2. Date Revised 2022-12-21
Further Info :

Pubmed ID

36241418

DOI: Digital Object Identifier

10.1002/bmc.5525

Related Literature

Article Analysis
・Effects of voriconazole・Effects of fluconazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.