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Preclinical toxicological assessment of levothyroxine and liothyronine Maillard impurities.
Author: AgarwalAnju, AsifMuhammad, BhondavePratik, DeshmukhRajeev, SinganaSuresh B, VinchurkarMohini
Original Abstract of the Article :
Following the introduction of new stability-indicating related substances methods, an unknown impurity was observed in levothyroxine (LeMI) and liothyronine (LiMI) tablets (ADVANZ PHARMA) in concentrations ≥1.0%, from 6 months of storage onwards. The impurity was identified as a Maillard condensatio...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618099/
データ提供:米国国立医学図書館(NLM)
Levothyroxine and Liothyronine: Unveiling Hidden Impurities
The world of pharmaceutical manufacturing is a complex one, with a constant focus on ensuring the purity and safety of medications. This study sheds light on the presence of Maillard condensation products, unexpected impurities, in levothyroxine and liothyronine tablets. The researchers investigated the potential toxicological effects of these impurities.
Maillard Products: Unforeseen Guests in Pharmaceutical Preparations
The study identifies a previously unknown impurity, a Maillard condensation product, in levothyroxine and liothyronine tablets. These impurities can arise during storage, potentially affecting the quality and safety of the medication. It's like finding a hidden oasis in the desert, only to discover that it's contaminated with harmful substances.
Navigating the Desert of Pharmaceutical Safety
This research highlights the critical importance of ongoing monitoring and testing of pharmaceutical products to ensure their purity and safety. It's a reminder that vigilance is key in safeguarding the health of patients who rely on these medications. Just like a camel diligently searching for safe water sources in the desert, we must be attentive to the potential presence of unseen hazards in the pharmaceutical world.
Dr.Camel's Conclusion
This study underscores the complexities of pharmaceutical manufacturing and the importance of rigorous quality control measures. It's a reminder that even seemingly innocuous impurities can have significant consequences. Just like a camel carefully navigating the desert's treacherous landscape, we must approach pharmaceutical safety with a cautious and vigilant mindset.
Date :
- Date Completed n.d.
- Date Revised 2022-11-05
Further Info :
Related Literature
English
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