Survival and functional recovery of primary cortical neurons exposed to actinomycin D.

Author: LeeGum Hwa, LeeSeong-Eun

Paper Details 
Original Abstract of the Article :
Actinomycin D (ActD) is an antineoplastic antibiotic that has been commonly used for the treatment of various tumors, including Wilms' tumor, rhabdomyosarcoma, and gestational trophoblastic neoplasia. Recent studies have proposed actinomycin D (ActD) as a novel therapeutic candidate for glioblastoma...See full text at original site
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引用元:
https://doi.org/10.1016/j.bbrc.2022.10.083

データ提供:米国国立医学図書館(NLM)

Actinomycin D: A Double-Edged Sword in Glioblastoma Treatment

The fight against glioblastoma, an aggressive brain tumor, is a complex and challenging battle. This study investigates the potential of actinomycin D, a potent antineoplastic antibiotic, as a novel therapeutic agent for glioblastoma. The researchers explored the use of actinomycin D to target and destroy glioblastoma cells, like a skilled warrior aiming to conquer a formidable enemy in a desert landscape. While the study found that actinomycin D showed promise in reducing tumor growth and prolonging survival in preclinical models, it also identified potential toxic effects on healthy brain cells, highlighting the need for careful consideration and optimized treatment strategies.

Actinomycin D: Navigating the Complexities of Brain Tumor Treatment

This study underscores the delicate balance that must be struck in treating glioblastoma. Just as a desert traveler must carefully navigate the treacherous terrain, oncologists need to weigh the potential benefits of actinomycin D against its potential toxic effects, aiming to maximize therapeutic efficacy while minimizing collateral damage to healthy cells.

Protecting the Brain: A Crucial Consideration in Glioblastoma Treatment

This research emphasizes the critical importance of protecting healthy brain cells during glioblastoma treatment. It's like shielding a precious oasis in the desert from a encroaching sandstorm. Future research should focus on developing strategies to target glioblastoma cells more effectively while minimizing the toxic effects on surrounding neurons and glial cells.

Dr. Camel's Conclusion

This study, like a desert explorer navigating a challenging landscape, sheds light on the complex terrain of glioblastoma treatment. The researchers' findings offer valuable insights into the potential of actinomycin D as a therapeutic agent, while also raising crucial concerns about its neurotoxicity. By understanding these complexities, we can continue to refine our treatment strategies, aiming to provide the most effective and safe care for individuals battling this devastating disease.

Date :
  1. Date Completed 2022-11-16
  2. Date Revised 2022-12-08
Further Info :

Pubmed ID

36332475

DOI: Digital Object Identifier

10.1016/j.bbrc.2022.10.083

Related Literature

SNS
PICO Info
in preparation
Languages

English

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