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Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios.

Author: ChesneyEdward, ChesterLucy, De MicheliAndrea, EnglundAmir, FreemanTom P, Fusar-PoliPaolo, HodsollJohn, McGuirePhilip, MurrayRobin M, OliverDominic, SoviSimina, StrangJohn, WilsonJack

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the effectiveness of CBD in mitigating the harmful effects of THC. As cannabis policies become more permissive, understanding the potential risks and benefits of cannabis use is crucial. This study examined the effects of varying CBD:THC ratios in cannabis on cognitive function, psychotic symptoms, and other subjective, pleasurable, and physiological effects. The study found that CBD did not significantly modulate the adverse effects of THC on cognitive function, psychotic symptoms, or other measures. This suggests that CBD does not protect against the acute adverse effects of THC at common CBD:THC ratios found in medicinal and recreational cannabis products.
Paper Details　
Original Abstract of the Article :
As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce the harmful effects of cannabis use. This study aimed to determine if increasing the CBD content of cannabis can reduce its harmful effects. Forty-six healthy, infrequent cannabi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156730/

データ提供：米国国立医学図書館（NLM）

CBD vs THC: A Desert Duel for Cannabis Safety

As cannabis use becomes more prevalent, understanding its potential risks and mitigating factors is crucial. This research, like a scientific expedition exploring the complexities of cannabis, investigates the role of cannabidiol (CBD) in reducing the harmful effects of tetrahydrocannabinol (THC), the psychoactive component of cannabis. The study involved 46 healthy, infrequent cannabis users who participated in a double-blind, randomized trial, inhaling cannabis with varying CBD:THC ratios. The results, like a compass guiding us through the intricacies of cannabis effects, showed that CBD did not significantly reduce the cognitive impairments or psychotic symptoms associated with THC. It’s like trying to quench a desert thirst with a mirage – the promise of relief is there, but it ultimately proves elusive.

CBD Doesn't Mitigate THC's Effects

This research, like a stark reminder of the desert’s harsh realities, demonstrates that CBD does not effectively protect against the adverse effects of THC. It's like trying to tame a wild sandstorm with a gentle breeze - the effort is there, but the storm remains powerful. This finding is significant for understanding the potential risks associated with cannabis use, particularly in individuals with pre-existing mental health conditions.

Navigating the Desert of Cannabis Use

This research sheds light on the complex relationship between CBD and THC. It’s like discovering a new desert oasis, offering valuable insights for navigating the challenging terrain of cannabis use. This knowledge is crucial for informed decision-making about cannabis policy and public health strategies.

Dr.Camel's Conclusion

This research, like a weathered traveler navigating a desert landscape, reveals the complex and sometimes unpredictable nature of cannabis. While CBD holds promise in various therapeutic applications, it does not appear to mitigate the cognitive and psychological effects of THC. This information is essential for making informed choices about cannabis use and ensuring the safety of individuals, especially those with pre-existing mental health concerns.

Date :
  1. Date Completed 2023-05-05
  2. Date Revised 2023-05-11
Further Info :

Pubmed ID

36380220

DOI: Digital Object Identifier

PMC10156730

Related Literature

Article Analysis
・Effects of cannabidiol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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