Anti-programmed death-1 inhibitor nivolumab-induced immune-related adverse events: hepatitis, renal insufficiency, myositis, vitiligo, and hypothyroidism: a case-based review.

Author: BenićMirjana Stanić, ZekićTatjana

Paper Details 
Original Abstract of the Article :
Nivolumab (NIVO) is a monoclonal antibody used to treat renal cell cancer. It is an anti-programmed death-1 (anti-PD-1) inhibitor, enhancing the tumor-targeted immune response of T lymphocytes, resulting in immune-mediated adverse events (AEs). We present five immunological AEs in a single patient t...See full text at original site
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引用元:
https://doi.org/10.1007/s00296-022-05247-5

データ提供:米国国立医学図書館(NLM)

Nivolumab-Induced Immune-Related Adverse Events: A Case Study

In the field of cancer immunotherapy, the use of checkpoint inhibitors, such as nivolumab, has revolutionized treatment approaches. These drugs work by unleashing the body's immune system to fight cancer cells. However, like a desert mirage, these powerful therapies can sometimes have unexpected consequences. This case study explores the complex landscape of immune-related adverse events (AEs) associated with nivolumab treatment.

The Impact of Nivolumab on a Patient's Health

The case presented highlights the potential for nivolumab to induce various immunological AEs, including hepatitis, renal insufficiency, myositis, vitiligo, and hypothyroidism. This serves as a stark reminder that even with the promise of new therapies, careful monitoring and prompt intervention are crucial. It's like navigating a desert with a GPS – a powerful tool that requires careful attention to avoid unforeseen hazards.

Navigating the Side Effects of Immunotherapy: A Desert Oasis of Hope

The case study underscores the importance of being vigilant about potential side effects associated with immunotherapy. Early detection and intervention, such as using glucocorticoids, can effectively manage these adverse events. The findings emphasize the need for personalized approaches and comprehensive monitoring to ensure that patients receive the optimal benefits from these life-saving therapies.

Dr.Camel's Conclusion

While immunotherapy offers hope for many cancer patients, it's important to remember that these powerful therapies can sometimes come with unforeseen challenges. The findings of this case study provide valuable insights into the potential side effects of nivolumab and the importance of careful monitoring to navigate these unexpected desert landscapes.

Date :
  1. Date Completed 2023-02-28
  2. Date Revised 2023-02-28
Further Info :

Pubmed ID

36449057

DOI: Digital Object Identifier

10.1007/s00296-022-05247-5

Related Literature

SNS
PICO Info
in preparation
Languages

English

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