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Carborane Analogues of Fenoprofen Exhibit Improved Antitumor Activity.

Author: Hey-HawkinsEvamarie, LaubeMarkus, LönneckePeter, Maksimović-IvanićDanijela, MijatovićSanja, MojićMarija, PietzschJens, UseiniLiridona

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Fenoprofen, a nonsteroidal anti-inflammatory drug (NSAID), inhibits both COX-1 and COX-2, leading to side effects. This study explored structural modifications of fenoprofen using carborane clusters to enhance COX-2 selectivity and antitumor potential. Carborane analogues exhibited stronger antitumor potential compared to aryl-based compounds.
Paper Details　
Original Abstract of the Article :
Fenoprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) against rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout. Like other NSAIDs, fenoprofen inhibits the synthesis of prostaglandins by blocking both cyclooxygenase (COX) isoforms, COX-1 the "house-k...See full text at original site
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引用元：
https://doi.org/10.1002/cmdc.202200583

データ提供：米国国立医学図書館（NLM）

Carborane Analogues: A Novel Approach to Cancer Therapy

The field of cancer research is a relentless pursuit of new treatments and therapies. This study, published in the Journal of Medicinal Chemistry, explores the potential of carborane-based analogues of fenoprofen, a nonsteroidal anti-inflammatory drug (NSAID), as antitumor agents. The researchers investigated the antitumor activity of these carborane analogues and compared them to their aryl-based counterparts. Carboranes are unique boron-containing clusters that have gained interest in drug development due to their unique chemical and biological properties.

A Promising New Direction

The study found that the carborane analogues exhibited stronger antitumor potential compared to their aryl-based counterparts. This suggests that incorporating carborane clusters into the structure of existing drugs may enhance their antitumor activity. It's like discovering a new type of desert plant with potent medicinal properties.

Potential for Personalized Cancer Treatment

This research opens up exciting avenues for developing new and more effective cancer therapies. The discovery of carborane analogues with enhanced antitumor activity has the potential to revolutionize cancer treatment, offering new hope for patients. It's like finding a hidden well in the desert, providing a source of healing and renewal.

Dr.Camel's Conclusion

This study demonstrates the potential of carborane-based drug development as a promising new direction for cancer therapy. The enhanced antitumor activity of these analogues offers a new avenue for exploring more effective and personalized cancer treatments.

Date :
  1. Date Completed 2023-03-03
  2. Date Revised 2023-03-19
Further Info :

Pubmed ID

36583943

DOI: Digital Object Identifier

10.1002/cmdc.202200583

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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