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Antinociceptive effects of nortriptyline and desipramine hydrochloride in Speke's hinge-back tortoise (Kinixys Spekii).

Author: AbelsonKlas S P, KanuiTitus I, MakauChristopher M, TowettPhilemon K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Nortriptyline and desipramine hydrochloride were found to have antinociceptive effects in Speke's hinge-back tortoise, primarily in chemical inflammatory pain, but not thermal pain. Excessive salivation was the most common side effect observed with higher doses of both drugs.
Paper Details　
Original Abstract of the Article :
Some of the most commonly used analgesic drugs in animals are of questionable efficacy or present adverse side effects among the various species of reptiles. Tricyclic antidepressants have been demonstrated to have antinociceptive effects in several animal models of pain and could be a good alternat...See full text at original site
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引用元：
https://doi.org/10.1111/fcp.12867

データ提供：米国国立医学図書館（NLM）

Exploring New Pain Relief Options for Speke's Hinge-Back Tortoise

Pain management is a crucial aspect of animal care, and researchers are constantly seeking better treatments for our furry, feathered, and scaled friends. This study investigates the potential of tricyclic antidepressants, a class of drugs known for their antinociceptive (pain-relieving) properties, in treating pain in Speke's hinge-back tortoise.

The researchers conducted a series of nociceptive (pain-related) tests on tortoises, evaluating the effects of nortriptyline and desipramine hydrochloride on various types of pain. They found that these drugs, at certain doses, could significantly reduce nocifensive behavior (painful responses) in tortoises.

Tricyclic Antidepressants: A Potential New Avenue for Pain Management in Reptiles

This study suggests that tricyclic antidepressants could be a valuable tool for managing pain in tortoises. The findings highlight the potential of these drugs for treating chemical-induced pain in reptiles, opening new avenues for managing pain in these unique creatures.

Navigating the World of Animal Pain Relief: Recognizing the Need for Species-Specific Treatments

This study emphasizes the importance of species-specific approaches to pain management in animals. It underscores the need for further research to identify safe and effective pain relief options for different species, taking into account their unique physiological characteristics.

Dr.Camel's Conclusion

Sometimes the best solutions for pain come from unexpected places, like finding a healing plant in the middle of a desert! This research suggests that tricyclic antidepressants may provide relief for tortoises, but more research is needed to understand their full potential and ensure safe use.

Date :
  1. Date Completed 2023-05-12
  2. Date Revised 2023-05-12
Further Info :

Pubmed ID

36617732

DOI: Digital Object Identifier

10.1111/fcp.12867

SNS
PICO Info
in preparation
Languages

English

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