Long-term effects of beta-adrenergic blockade with nadolol on hepatic and renal haemodynamics and function in cirrhotics.

Author: AngeliP, BolognesiM, FinucciG F, GattaA, MerkelC, RuolA, SacerdotiD

Paper Details 
Original Abstract of the Article :
Non-cardioselective beta-blockers are used for prevention of re-bleeding from oesophageal varices in cirrhotics with portal hypertension. Nadolol, a non-cardioselective beta-blocker with a low liposolubility and a low hepatic metabolism, has been demonstrated to decrease portal pressure in cirrhotic...See full text at original site
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引用元:
https://doi.org/10.1111/j.1475-097x.1987.tb00180.x

データ提供:米国国立医学図書館(NLM)

Nadolol: A Long-Term Solution for Managing Portal Hypertension in Cirrhosis

Cirrhosis, a serious liver disease, can lead to portal hypertension, a condition marked by elevated pressure in the portal vein. This can lead to complications such as esophageal varices, which can bleed and cause life-threatening complications. This study investigates the long-term effects of nadolol, a beta-blocker, on hepatic and renal hemodynamics and function in patients with cirrhosis and portal hypertension.

Nadolol: A Potential Long-Term Solution for Portal Hypertension

The study revealed that nadolol effectively decreased portal pressure in patients with cirrhosis, even after prolonged treatment. Importantly, nadolol did not adversely affect hepatic or renal function, making it a potentially safe and effective long-term treatment option for managing portal hypertension in cirrhosis. These results underscore the potential of nadolol to improve the management and outcomes of this challenging condition.

Managing Portal Hypertension: Understanding the Benefits and Risks

This research provides important insights into the long-term management of portal hypertension in cirrhosis. Nadolol, a beta-blocker, emerges as a potential solution for effectively controlling portal pressure without compromising hepatic or renal function. This study emphasizes the importance of personalized medical care and long-term follow-up to ensure optimal management of this complex condition. Like a desert traveler adapting to the changing landscape, healthcare providers must carefully monitor and adjust treatment plans over time to ensure the best possible outcomes for patients with cirrhosis and portal hypertension.

Dr. Camel's Conclusion

Cirrhosis, a formidable foe, can lead to portal hypertension, a condition that can be as challenging to manage as a desert sandstorm. This study highlights the potential of nadolol, a beta-blocker, to effectively control portal pressure over the long term, without compromising hepatic or renal function. Just as a skilled desert navigator charts a course through treacherous terrain, healthcare providers must carefully navigate the complexities of managing portal hypertension in cirrhosis, ensuring the well-being of their patients.

Date :
  1. Date Completed 1987-12-17
  2. Date Revised 2019-09-19
Further Info :

Pubmed ID

3665396

DOI: Digital Object Identifier

10.1111/j.1475-097x.1987.tb00180.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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