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Long-Term Treatment and Effect of Discontinuation of Calcifediol in Postmenopausal Women with Vitamin D Deficiency: A Randomized Trial.

Author: Alhambra ExpósitoMaría Rosa, BouillonRoger, BrandiMaria Luisa, Cereto CastroFernando, ChinchillaSandra P, Del Pino-MontesJavier, Dueñas-LaitaAntonio, Fernández-HernandoNieves, GalarragaBernat, Gallego LópezLaura, González-MacíasJesús, Gómez-AlonsoCarlos, Hernández-HerreroGonzalo, JódarEsteban, NeyroJosé Luis, Olmos MartínezJosé Manuel, Pérez-CastrillónJosé Luis, Quesada-GómezJosé Manuel

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This clinical trial compared the efficacy and safety of monthly calcifediol 0.266 mg versus cholecalciferol 25,000 IU in postmenopausal women with vitamin D deficiency. The study found that long-term treatment with monthly calcifediol was effective and safe, producing stable and sustained 25(OH)D concentrations with no associated safety concerns. Calcifediol had a faster onset of action compared to cholecalciferol.
Paper Details　
Original Abstract of the Article :
Vitamin D plays a major role in bone health and probably also in multiple extraskeletal acute and chronic diseases. Although supplementation with calcifediol, a vitamin D metabolite, has demonstrated efficacy and safety in short-term clinical trials, its effects after long-term monthly administratio...See full text at original site
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引用元：
https://doi.org/10.1002/jbmr.4776

データ提供：米国国立医学図書館（NLM）

Calcifediol: A Long-Term Solution for Vitamin D Deficiency

This study embarks on a journey into the world of vitamin D research, investigating the long-term effects of calcifediol, a vitamin D metabolite, on postmenopausal women with vitamin D deficiency. The researchers conducted a large-scale, randomized controlled trial to compare the efficacy and safety of monthly calcifediol treatment with cholecalciferol, another form of vitamin D. Their findings suggest that calcifediol is an effective and safe treatment option for maintaining adequate vitamin D levels over a longer period.

Calcifediol: A Reliable Source of Vitamin D

The study's results demonstrate that long-term monthly calcifediol treatment effectively maintains stable vitamin D levels in postmenopausal women with deficiency. This is like finding a reliable source of water in the desert, ensuring consistent hydration and supporting overall health.

Maintaining Vitamin D Levels: A Vital Journey

This research highlights the importance of maintaining adequate vitamin D levels, especially in postmenopausal women, who are at increased risk of deficiency. It's like embarking on a long desert journey, knowing that proper hydration and nourishment are essential for staying healthy and strong.

Dr.Camel's Conclusion

As a camel, I have learned to appreciate the importance of water for survival in the desert. This study emphasizes the importance of vitamin D in maintaining overall health, reminding us to seek solutions that ensure adequate levels of this vital nutrient.

Date :
  1. Date Completed 2023-04-14
  2. Date Revised 2023-05-17
Further Info :

Pubmed ID

36661855

DOI: Digital Object Identifier

10.1002/jbmr.4776

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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