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Efficacy and tolerability of pharmacological treatments for insomnia in adults: A systematic review and network meta-analysis.

Author: BaoYan-Ping, ChangXiang-Wen, DengJia-Hui, LiYang-Yang, LuLin, QueJian-Yu, ShiJie, ShiLe, SunHong-Qiang, SunWei, TangXiang-Dong, TengTeng, VitielloMichael V, XiangYa-Jie, YuanKai, YueJing-Li, ZhengJun-Wei, ZhouXin-Yu

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Insomnia is a common problem, and there are many medications available to treat it. This review of 69 studies found that orexin receptor antagonists (ORAs) were more effective than other drugs for insomnia, with good tolerability, while Z-drugs were also effective but had a higher risk of side effects.
Paper Details　
Original Abstract of the Article :
Insomnia is one of the most common and burdensome disorders in adults. We compared and ranked insomnia medication on the basis of their efficacy and tolerability. We performed a systematic review and network meta-analysis of placebo-controlled or head-to-head randomized controlled trials for primary...See full text at original site
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引用元：
https://doi.org/10.1016/j.smrv.2023.101746

データ提供：米国国立医学図書館（NLM）

Insomnia: A Journey Through the Desert of Sleep

Insomnia is a common and often debilitating condition, impacting both physical and mental well-being. This systematic review and network meta-analysis explores the efficacy and tolerability of various pharmacological treatments for insomnia in adults. The authors compared 20 different medications across a range of studies, analyzing their effects on sleep latency, wake time after sleep onset, sleep efficiency, and sleep quality, as well as their safety profiles. The study is like a comprehensive guide through the vast desert of insomnia treatments, seeking to identify the most effective and safe options for those struggling to find restful sleep.

Orexins Receptor Antagonists: A New Oasis in the Desert of Insomnia

The study highlights the potential of orexin receptor antagonists (ORAs) as a promising treatment option for insomnia, demonstrating superior efficacy and tolerability compared to other medications. This finding is like discovering a hidden oasis in the desert of insomnia, offering a refreshing and effective solution to this challenging condition. The research suggests that ORAs may offer a more effective and well-tolerated approach to managing insomnia, potentially improving sleep quality and overall well-being for those affected by this disorder.

Navigating the Desert of Sleep: A Personalized Approach

The study underscores the importance of personalized approaches to insomnia treatment, acknowledging that different medications may have varying effects on different individuals. It’s like recognizing that the desert landscape can vary greatly, requiring different strategies for navigation depending on the terrain. The research encourages a personalized approach to insomnia treatment, considering individual factors and tailoring treatment plans to optimize outcomes.

Dr.Camel's Conclusion

This systematic review and network meta-analysis provides a comprehensive overview of pharmacological treatments for insomnia, offering valuable insights into the efficacy and tolerability of various medications. It’s like a seasoned traveler leading a caravan across the vast desert of insomnia, guiding those seeking restful sleep towards the most effective and safe options. The research underscores the importance of personalized approaches to insomnia treatment, ensuring that individuals find the best path towards a more restful and fulfilling sleep experience.

Date :
  1. Date Completed 2023-03-28
  2. Date Revised 2023-06-10
Further Info :

Pubmed ID

36701954

DOI: Digital Object Identifier

10.1016/j.smrv.2023.101746

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Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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