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Distinct brain activity alterations of treatment for bipolar disorders with psychotherapy and drug therapy: activation likelihood estimation meta-analysis.

Author: FanChuan, LiNi, LiXiaoming, LiangMeng, LuoJingyi, TaoQian, WenJialin, XueXinrong, YiPengcheng, ZhangHan, ZhangShuyu

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A meta-analysis of 21 studies using activation likelihood estimation found that psychotherapy and drug therapy for bipolar disorders (BDs) might have distinct effects on brain activity. Psychotherapy showed increased activation in frontal areas, suggesting a top-down effect, while drug therapy showed increased activation in limbic areas, suggesting a bottom-up effect.
Paper Details　
Original Abstract of the Article :
BACKGROUNDS: Many studies suggest that both psychotherapy and drug therapy are effective in the treatment of bipolar disorders (BDs). However, the pathophysiology of both types of intervention has not been established definitively. METHODS: An activation likelihood estimation meta-analysis was perf...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/36722029

データ提供：米国国立医学図書館（NLM）

Psychotherapy vs. Drug Therapy for Bipolar Disorders: A Brain-Based Perspective

Bipolar disorder is a complex mental illness that can significantly impact a person's life. While both psychotherapy and drug therapy are often used to treat bipolar disorder, it remains unclear how these treatments affect the brain. This meta-analysis aimed to identify the distinct brain activity alterations associated with psychotherapy and drug therapy for bipolar disorder.

Distinct Brain Activity Patterns for Psychotherapy and Drug Therapy

The meta-analysis revealed that psychotherapy and drug therapy may target different brain regions, suggesting distinct mechanisms of action. Psychotherapy was associated with increased activation in brain areas involved in executive function and language processing, while drug therapy was linked to changes in brain regions associated with emotion regulation and reward processing. These findings suggest that both treatments may be effective in treating bipolar disorder, but through different pathways.

Understanding the Brain: A Key to Better Treatment for Bipolar Disorder

This meta-analysis provides valuable insights into the brain mechanisms underlying psychotherapy and drug therapy for bipolar disorder. Understanding these differences could lead to more targeted and effective treatment approaches for individuals with this complex mental illness. It's like deciphering the intricate map of the brain to find the right path to recovery.

Dr.Camel's Conclusion

This comprehensive meta-analysis offers valuable insights into the distinct brain activity alterations associated with psychotherapy and drug therapy for bipolar disorder. The findings suggest that these two treatments may target different brain regions and mechanisms, highlighting the importance of personalized approaches to treatment. It's like navigating a vast desert landscape, where different paths lead to the same oasis, but through different routes. Understanding these brain-based differences could pave the way for more effective and personalized treatments for bipolar disorder.

Date :
  1. Date Completed 2023-05-04
  2. Date Revised 2023-06-07
Further Info :

Pubmed ID

36722029

DOI: Digital Object Identifier

S0033291722003889

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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