Paper Details

  1. Home
  2. Paper Details

The impact of endoxifen-guided tamoxifen dose reductions on endocrine side-effects in patients with primary breast cancer.

Author: BraalC L, BuijsS M, DroogerJ C, HoopE Oomen-de, JagerA, KoolenS L W, MathijssenR H J, VastbinderM B, van RosmalenM M, van Rossum-SchornagelQ C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tamoxifen is a widely used drug for the treatment of hormone-sensitive breast cancer. However, many patients experience side effects that lead to non-compliance. This study investigated whether endoxifen-guided tamoxifen dose reduction could lead to fewer side effects.
Paper Details　
Original Abstract of the Article :
Tamoxifen is important in the adjuvant treatment of hormone-sensitive breast cancer and substantially reduces recurrence; however, almost 50% of patients are non-compliant mainly due to side-effects. The aim of this study was to investigate whether endoxifen-guided tamoxifen dose reduction could lea...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024121/

データ提供：米国国立医学図書館（NLM）

Personalized Tamoxifen Therapy: Optimizing Dosing for Improved Patient Outcomes

Tamoxifen, a widely prescribed medication for hormone-sensitive breast cancer, significantly reduces the risk of recurrence. However, many patients experience side effects that can lead to non-compliance. Researchers are exploring ways to personalize tamoxifen therapy to optimize its effectiveness while minimizing side effects.

Endoxifen-Guided Dose Reductions: A Promising Strategy for Tamoxifen Therapy

This study investigates the impact of endoxifen-guided tamoxifen dose reduction on endocrine side effects in patients with primary breast cancer. Endoxifen is a metabolite of tamoxifen, responsible for its therapeutic activity. By monitoring endoxifen levels, clinicians can adjust tamoxifen dosage to ensure optimal therapeutic response while minimizing side effects.

The Potential of Personalized Therapy to Improve Patient Adherence and Outcomes

The study suggests that endoxifen-guided dose reduction may lead to fewer side effects, potentially improving patient adherence to tamoxifen therapy. This strategy holds promise for improving patient outcomes by maximizing the benefits of tamoxifen while minimizing the risks associated with its use.

Dr. Camel's Conclusion

Just as a camel carefully adjusts its pace to navigate the vast and unpredictable desert, healthcare providers are striving to personalize tamoxifen therapy to achieve optimal outcomes for breast cancer patients. By monitoring endoxifen levels, clinicians can tailor treatment to individual needs, ensuring the best possible response with minimal side effects.

Date :
  1. Date Completed 2023-03-07
  2. Date Revised 2023-03-24
Further Info :

Pubmed ID

36753991

DOI: Digital Object Identifier

PMC10024121

Related Literature

Article Analysis
・Side Effects of tamoxifen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.