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Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans.

Author: BreimerD D, CohenA F, LandG S, PeckA W, WintonC, YuenW C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Lamotrigine, a new anticonvulsant, showed linear pharmacokinetics with oral doses up to 240 mg. Repeated administration did not demonstrate autoinduction of metabolism. No clinically significant side effects were observed during a 7-day study.
Paper Details　
Original Abstract of the Article :
The pharmacokinetics of lamotrigine, a new anticonvulsant, were studied in three studies in normal volunteers. In the first study, five subjects received oral doses of lamotrigine up to 240 mg. A linear relationship was observed between dose administration and both peak drug concentration and AUC. I...See full text at original site
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引用元：
https://doi.org/10.1038/clpt.1987.193

データ提供：米国国立医学図書館（NLM）

Lamotrigine: A New Anticonvulsant's Journey Through the Body

This article takes us on a journey through the pharmacokinetics of lamotrigine, a new anticonvulsant, exploring its absorption, distribution, metabolism, and elimination in normal humans. It's like tracing the path of a camel caravan through a vast desert, observing how it interacts with the environment and navigates the challenges along the way.

A Linear Pathway: Understanding Lamotrigine's Dosage Response

The study revealed a linear relationship between the dose of lamotrigine administered and both peak drug concentration and area under the curve (AUC). This means that as the dose increases, the amount of lamotrigine in the body also increases proportionally. It's like a caravan's journey across a flat desert plain, where the distance traveled is directly proportional to the time spent on the journey.

A Long and Steady Journey: Exploring Lamotrigine's Elimination

The study found that the mean elimination half-life (t1/2) of lamotrigine was 24.1 hours. This means that it takes approximately 24.1 hours for the amount of lamotrigine in the body to reduce by half. This relatively long half-life suggests that lamotrigine is absorbed and eliminated slowly, offering sustained therapeutic effects. It's like a caravan's journey across a vast desert, where the journey is long and steady, with the caravan persisting for a considerable duration.

Dr.Camel's Conclusion

This study provides a comprehensive understanding of lamotrigine's pharmacokinetics, revealing its linear dose-response relationship and prolonged elimination half-life. It's like having a detailed roadmap of lamotrigine's journey through the body, allowing healthcare professionals to make informed decisions about dosage and treatment duration. This research is a valuable contribution to the field of anticonvulsant therapy, offering new insights into the behavior of this promising drug.
Date :
  1. Date Completed 1987-12-29
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

3677542

DOI: Digital Object Identifier

10.1038/clpt.1987.193

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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