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UPLC-MS/MS Based Identification and Quantification of a Novel Dual Orexin Receptor Antagonist in Plasma Samples by Validated SWGTOX Guidelines.
Author: AkhtarAli, AliEssam A, AlshememryAbdullah, ImamFaisal, IqbalMuzaffar, KalamMohd Abul
Original Abstract of the Article :
Lemborexant (LEM) is a novel dual orexin receptor antagonist (DORA), recently approved for the treatment of insomnia. As with other DORAs, LEM has potential of abuse and therefore placed in Schedule IV class by the United States Drug Enforcement Administration (USDEA). In this study, a sensitive and...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959124/
データ提供:米国国立医学図書館(NLM)
Accurate Quantification of Lemborexant in Plasma: A New Tool for Drug Monitoring
This research describes the development and validation of a sensitive and accurate method for measuring lemborexant, a new drug used to treat insomnia, in human plasma samples. The researchers employed a [UPLC-MS/MS] technique to quantify lemborexant levels. The method was validated according to the stringent [SWGTOX] guidelines, ensuring its accuracy and reliability. This method can be used for pharmacokinetic studies and drug monitoring, providing valuable information for understanding how lemborexant works in the body and for ensuring its safe and effective use.
Reliable Drug Monitoring: Ensuring Patient Safety
The development of a validated method for measuring lemborexant in plasma is crucial for ensuring patient safety. This method can help healthcare providers monitor drug levels in patients, adjusting treatment regimens as needed to optimize therapeutic effects and minimize potential adverse effects.
Progress in Drug Monitoring: A Step Forward for Patient Care
This research represents a significant advancement in drug monitoring technology. The development of this accurate and reliable method for measuring lemborexant levels in plasma enhances our ability to understand and manage this new drug, ultimately leading to improved patient care.
Dr.Camel's Conclusion
Just like a camel navigating a vast desert, the journey of drug development requires careful monitoring and evaluation. This research provides a valuable tool for charting the course of lemborexant treatment, ensuring its safe and effective use.
Date :
- Date Completed n.d.
- Date Revised 2023-03-03
Further Info :
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