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Purinergic approach to effective glioma treatment with temozolomide reveals enhanced anti-cancer effects mediated by P2X7 receptor.

Author: CzachSylwia, CzarneckaJoanna, NowakWiesław, RoszekKatarzyna, SzymczakBartosz

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the interplay between purinergic signaling and temozolomide (TMZ), a chemotherapy drug, in human glioma cells. The findings suggest that the combination of ATP and TMZ may be more effective in treating glioma cells, potentially leading to shorter treatment durations and reduced side effects.
Paper Details　
Original Abstract of the Article :
The purinergic signaling pathway is the oldest evolutionary transmitter system that regulates a wide array of physiological and pathophysiological processes in central nervous system. However, the question of how the purinergic compounds interact with administrated drugs is rarely addressed. We aime...See full text at original site
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引用元：
https://doi.org/10.1016/j.cellsig.2023.110641

データ提供：米国国立医学図書館（NLM）

Purinergic Signaling: A New Frontier in Glioma Treatment with Temozolomide

The realm of cancer treatment is a vast and often treacherous desert. In this research, we explore a new approach to treating glioma, a type of brain tumor, by utilizing the ancient signaling pathway called purinergic signaling. It's like discovering a hidden spring in the desert, offering a novel way to fight this formidable foe.

Harnessing the Power of Purinergic Signaling

The study highlights the potential of combining the chemotherapy drug temozolomide (TMZ) with purinergic signaling, specifically through the P2X7 receptor. It's like finding a way to enhance the effects of existing medications by tapping into a previously unexplored avenue. The research indicates that this combination can be more effective and less toxic than using TMZ alone. It's like finding a more efficient and safer way to navigate the desert of cancer treatment.

A New Pathway for Glioma Treatment

This research provides hope for patients battling gliomas, suggesting a more effective and potentially safer approach to treatment. It's like finding a new oasis in the desert of cancer research, providing a promising path towards better outcomes.

Dr. Camel's Conclusion

The research on purinergic signaling opens new avenues for treating glioma, offering a beacon of hope in the desert of cancer research. It's a reminder that even in the harshest landscapes, there is always potential for discovery and innovation. It's like finding a hidden treasure in the desert, a valuable discovery with the potential to transform the lives of patients.

Date :
  1. Date Completed 2023-04-10
  2. Date Revised 2023-04-11
Further Info :

Pubmed ID

36858191

DOI: Digital Object Identifier

10.1016/j.cellsig.2023.110641

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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