Genome-based characterization of conjugative IncHI1B plasmid carrying carbapenemase genes bla<sub>VIM-1</sub>, bla<sub>IMP-23</sub>, and truncated bla<sub>OXA-256</sub>in Klebsiella pneumoniae NTU107224.

Author: ChenYu-Chen, DuongTran Thi Thuy, HsuehPo-Ren, HuangYu-Tsung, KaoCheng-Yen, KuoPei-Yun, ThuyTran Thi Dieu, WenLi-Li

Paper Details 
Original Abstract of the Article :
The wide dissemination of plasmids carrying antibiotic resistance determinants among bacteria is a severe threat to global public health. Here, we characterized an extensively drug-resistant (XDR) Klebsiella pneumoniae NTU107224 by whole genome sequencing (WGS) in combination with phenotypic tests. ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.meegid.2023.105420

データ提供:米国国立医学図書館(NLM)

Dissemination of Carbapenemase-Carrying Plasmids: A Threat to Public Health

This study delves into the world of antibiotic resistance, a growing concern for global health. It's like a desert landscape, where antibiotic-resistant bacteria are spreading and becoming increasingly difficult to control. The study focuses on a particular strain of Klebsiella pneumoniae (NTU107224) that carries multiple antibiotic resistance genes, including those for carbapenemases, on a conjugative IncHI1B plasmid. The research explores the genetic characteristics of this plasmid, its transferability to other bacteria, and its potential impact on bacterial virulence. The authors emphasize the importance of understanding the mechanisms of antibiotic resistance and developing strategies to combat its spread.

Dissemination of Carbapenemase-Carrying Plasmids: A Growing Concern

This research highlights the threat posed by the dissemination of plasmids carrying antibiotic resistance genes, particularly carbapenemases. It's like a desert storm, where antibiotic resistance is spreading rapidly and threatening our ability to treat bacterial infections. The study's findings emphasize the importance of ongoing surveillance, rapid diagnostic testing, and the development of new antimicrobial agents to combat this growing challenge.

A Call to Action for Combating Antibiotic Resistance

This study underscores the urgency of addressing antibiotic resistance. It's like a desert expedition, where researchers are racing against time to find solutions to this pressing global health crisis. The study's findings call for concerted efforts to develop new drugs, implement infection control measures, and promote responsible antibiotic use to protect public health and prevent the emergence of untreatable infections.

Dr.Camel's Conclusion

The desert of antibiotic resistance is a harsh and unforgiving landscape, where bacteria are constantly evolving and developing new ways to outwit our antibiotics. This study serves as a reminder of the ongoing battle against antibiotic resistance and the importance of continued research and vigilance in combating this growing threat. It's a journey that requires collaboration, innovation, and a commitment to preserving the effectiveness of our antibiotics for future generations.

Date :
  1. Date Completed 2023-04-04
  2. Date Revised 2023-05-05
Further Info :

Pubmed ID

36868443

DOI: Digital Object Identifier

10.1016/j.meegid.2023.105420

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.