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Genome-based characterization of conjugative IncHI1B plasmid carrying carbapenemase genes bla<sub>VIM-1</sub>, bla<sub>IMP-23</sub>, and truncated bla<sub>OXA-256</sub>in Klebsiella pneumoniae NTU107224.
Author: ChenYu-Chen, DuongTran Thi Thuy, HsuehPo-Ren, HuangYu-Tsung, KaoCheng-Yen, KuoPei-Yun, ThuyTran Thi Dieu, WenLi-Li
Original Abstract of the Article :
The wide dissemination of plasmids carrying antibiotic resistance determinants among bacteria is a severe threat to global public health. Here, we characterized an extensively drug-resistant (XDR) Klebsiella pneumoniae NTU107224 by whole genome sequencing (WGS) in combination with phenotypic tests. ...See full text at original site
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引用元:
https://doi.org/10.1016/j.meegid.2023.105420
データ提供:米国国立医学図書館(NLM)
Dissemination of Carbapenemase-Carrying Plasmids: A Threat to Public Health
This study delves into the world of antibiotic resistance, a growing concern for global health. It's like a desert landscape, where antibiotic-resistant bacteria are spreading and becoming increasingly difficult to control. The study focuses on a particular strain of Klebsiella pneumoniae (NTU107224) that carries multiple antibiotic resistance genes, including those for carbapenemases, on a conjugative IncHI1B plasmid. The research explores the genetic characteristics of this plasmid, its transferability to other bacteria, and its potential impact on bacterial virulence. The authors emphasize the importance of understanding the mechanisms of antibiotic resistance and developing strategies to combat its spread.
Dissemination of Carbapenemase-Carrying Plasmids: A Growing Concern
This research highlights the threat posed by the dissemination of plasmids carrying antibiotic resistance genes, particularly carbapenemases. It's like a desert storm, where antibiotic resistance is spreading rapidly and threatening our ability to treat bacterial infections. The study's findings emphasize the importance of ongoing surveillance, rapid diagnostic testing, and the development of new antimicrobial agents to combat this growing challenge.
A Call to Action for Combating Antibiotic Resistance
This study underscores the urgency of addressing antibiotic resistance. It's like a desert expedition, where researchers are racing against time to find solutions to this pressing global health crisis. The study's findings call for concerted efforts to develop new drugs, implement infection control measures, and promote responsible antibiotic use to protect public health and prevent the emergence of untreatable infections.
Dr.Camel's Conclusion
The desert of antibiotic resistance is a harsh and unforgiving landscape, where bacteria are constantly evolving and developing new ways to outwit our antibiotics. This study serves as a reminder of the ongoing battle against antibiotic resistance and the importance of continued research and vigilance in combating this growing threat. It's a journey that requires collaboration, innovation, and a commitment to preserving the effectiveness of our antibiotics for future generations.
Date :
- Date Completed 2023-04-04
- Date Revised 2023-05-05
Further Info :
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