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Oral mometasone furoate administration preserves anti-inflammatory action with fewer metabolic adverse effects in rats.

Author: AlmeidaMilena S, BruxelMaciel A, RafachoAlex, ZimathPriscila L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the effects of mometasone furoate (MF), a glucocorticoid, on inflammation and metabolism. It examines whether MF can maintain anti-inflammatory effects without significant metabolic side effects.
Paper Details　
Original Abstract of the Article :
Exogenous glucocorticoids (CGs) possess relevant therapeutic effects but exert diabetogenic actions when in excess. Thus, ligands with potential therapeutic applications and fewer adverse effects are needed. To this, we analyzed whether mometasone furoate (MF), a CG expected to cause fewer side effe...See full text at original site
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引用元：
https://doi.org/10.1016/j.bcp.2023.115486

データ提供：米国国立医学図書館（NLM）

Mometasone Furoate: A Potential Anti-inflammatory with Fewer Metabolic Side Effects

This study explores the potential of mometasone furoate (MF), a glucocorticoid medication, as an anti-inflammatory agent with fewer metabolic side effects. The researchers investigated the effects of oral MF administration on inflammation and metabolic parameters in rats. The study aimed to determine whether MF could maintain its anti-inflammatory efficacy while minimizing the adverse effects commonly associated with systemic glucocorticoid use. The researchers used a rat model to compare the effects of MF to other glucocorticoids, assessing both anti-inflammatory activity and metabolic parameters.

Mometasone Furoate: Balancing Anti-inflammatory Effects with Fewer Metabolic Side Effects

The study found that oral MF administration effectively reduced inflammation while exhibiting fewer metabolic side effects compared to other glucocorticoids. The results suggest that MF may be a promising alternative for treating inflammatory conditions, offering a balance between therapeutic efficacy and a reduced risk of metabolic complications. This has potential significance for patients who require long-term glucocorticoid therapy.

The Importance of Minimizing Glucocorticoid Side Effects

This research highlights the importance of minimizing the side effects associated with glucocorticoid use. The findings suggest that MF may offer a safer alternative for treating inflammatory conditions, minimizing the risk of metabolic disturbances. Just as a camel can thrive in the desert by conserving water, minimizing glucocorticoid side effects is crucial for optimizing patient well-being during long-term treatment.

Dr.Camel's Conclusion

This study presents compelling evidence for the potential of mometasone furoate (MF) as an anti-inflammatory agent with fewer metabolic side effects. The findings suggest that MF may offer a safer alternative for treating inflammatory conditions, minimizing the risk of metabolic disturbances. Just as a camel can thrive in the desert by conserving water, minimizing glucocorticoid side effects is crucial for optimizing patient well-being during long-term treatment.
Date :
  1. Date Completed 2023-03-28
  2. Date Revised 2023-03-29
Further Info :

Pubmed ID

36893817

DOI: Digital Object Identifier

10.1016/j.bcp.2023.115486

SNS
PICO Info
in preparation
Languages

English

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