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Crystallization of short-acting and intermediate-acting local anesthetics when mixed with adjuvants: a semiquantitative light microscopy analysis.

Author: FieglHeidi, GasteigerLukas, HoernerElisabeth, StundnerOttokar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This follow-up study is intended to clarify whether crystallization (A) also occurs in short-acting or intermediate-acting LA-adjuvant mixtures, (B) changes over time, and (C) is associated with the solutions' pH.
Paper Details　
Original Abstract of the Article :
The addition of adjuvants to short-acting local anesthetics (LA) is common practice in clinical routine to speed up block onset and decrease pain on injection. In a previous study, we observed the development of microscopic crystal precipitations after bupivacaine or ropivacaine were mixed with adju...See full text at original site
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引用元：
https://doi.org/10.1136/rapm-2023-104398

データ提供：米国国立医学図書館（NLM）

Local Anesthetics and Adjuvants: A Tale of Crystallization

Local anesthetics are crucial for managing pain during medical procedures, like a cool oasis in the desert of pain. This study, like a scientist meticulously examining the properties of sand, investigates the crystallization phenomenon that occurs when certain adjuvants are mixed with local anesthetics. The researchers aimed to understand this phenomenon and its potential implications for the efficacy and safety of local anesthetic solutions.

The Crystallization of Local Anesthetics: A Tale of Shifting Sands

This study, like an explorer observing the changing landscape of a desert, revealed that crystallization occurs when short-acting or intermediate-acting local anesthetics are mixed with adjuvants. The researchers found that crystallization can occur over time and is influenced by the solution's pH. It's like a delicate balance between the grains of sand, where changes in the environment can lead to unexpected transformations.

Understanding the Crystallization Phenomenon

This research underscores the importance of understanding the potential for crystallization when mixing local anesthetics with adjuvants. It's like carefully navigating a desert landscape, recognizing that even seemingly small changes can have a significant impact. The researchers' findings raise concerns about the potential impact of crystallization on the efficacy and safety of local anesthetic solutions, highlighting the need for further research to ensure optimal patient care.

Dr. Camel's Conclusion

This study sheds light on the unexpected phenomenon of crystallization when local anesthetics are mixed with adjuvants. The research highlights the importance of understanding this phenomenon and its potential implications for patient safety and treatment efficacy. Further research is needed to fully explore this intriguing aspect of local anesthetic solutions.

Date :
  1. Date Completed 2023-08-25
  2. Date Revised 2023-08-28
Further Info :

Pubmed ID

36928300

DOI: Digital Object Identifier

10.1136/rapm-2023-104398

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Languages

English

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