Psychiatric Adverse Effects of Montelukast-A Nationwide Cohort Study.

Author: BønnelykkeKlaus, EklöfJosefin, JordanAlexander, MeteranHowraman, SivapalanPradeesh, Stæhr JensenJens-Ulrik, ToennesenLouise Lindhardt, UlrikCharlotte Suppli

Paper Details 
Original Abstract of the Article :
BACKGROUND: Recent observational studies suggest that the leukotriene receptor antagonist montelukast may have neuropsychiatric adverse effects; however, results are conflicting. OBJECTIVE: To assess whether montelukast exposure in adults with asthma is associated with onset of neuropsychiatric adv...See full text at original site
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引用元:
https://doi.org/10.1016/j.jaip.2023.03.010

データ提供:米国国立医学図書館(NLM)

Montelukast and Neuropsychiatric Adverse Effects: A Nationwide Cohort Study

The human mind is a complex and delicate organ, and it's essential to understand how medications can affect its intricate workings. This research delves into the potential neuropsychiatric side effects of montelukast, a commonly prescribed medication for asthma. The study, conducted on a massive scale using Danish nationwide health registers, provides a comprehensive analysis of the relationship between montelukast exposure and the onset of neuropsychiatric adverse events. The researchers meticulously analyzed the data, using a statistical approach to identify any potential links between montelukast use and neuropsychiatric outcomes. The results of this study are particularly important, as they highlight a potential risk associated with montelukast, especially in younger individuals.

Montelukast Use and Neuropsychiatric Events

The study found a significant association between the initiation of montelukast and the use of neuropsychiatric medications, including antidepressants, antipsychotics, anxiolytics, and medication for attention-deficit/hyperactivity disorder. Interestingly, the researchers observed a higher risk of neuropsychiatric events in younger age groups. This finding is significant, as it raises concerns about the potential impact of montelukast on mental health, especially in individuals with pre-existing neuropsychiatric conditions or vulnerabilities.

Balancing the Benefits and Risks

Montelukast is a valuable medication for managing asthma, but it's crucial to weigh its potential benefits against the risks. This study emphasizes the importance of being vigilant for any neuropsychiatric changes in individuals taking montelukast, particularly in younger patients. Understanding these potential risks can help healthcare providers make informed decisions about prescribing montelukast and ensuring the safety and well-being of their patients.

Dr. Camel's Conclusion

Like the delicate balance of nature, the human body is a complex ecosystem, and medications can sometimes have unforeseen effects. This research serves as a reminder that even seemingly benign medications can have subtle impacts on our mental well-being. It's a valuable contribution to our understanding of drug safety, reminding us to always consider the potential risks and benefits of any medication we take, especially when it comes to our mental health.

Date :
  1. Date Completed 2023-07-10
  2. Date Revised 2023-11-20
Further Info :

Pubmed ID

36948487

DOI: Digital Object Identifier

10.1016/j.jaip.2023.03.010

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SNS
PICO Info
in preparation
Languages

English

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