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The reverse transcriptase inhibitor 3TC protects against age-related cognitive dysfunction.

Author: BurkeSamuel D, CavalierAlyssa N, GrantRandy A, LaRoccaThomas J, LarkDaniel S, LinkChristopher D, McEnteeCali M, NerguizianDavid, OsburnShelby C, SmithMeghan E, WahlDevin

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the potential role of transposable element (TE) transcripts in brain aging and cognitive decline. The study finds that the reverse transcriptase inhibitor 3TC improves cognitive function and reduces neuroinflammation in old mice, preserves neuronal health with aging, and enhances cognitive function in a mouse model of tauopathy.
Paper Details　
Original Abstract of the Article :
Aging is the primary risk factor for most neurodegenerative diseases, including Alzheimer's disease. Major hallmarks of brain aging include neuroinflammation/immune activation and reduced neuronal health/function. These processes contribute to cognitive dysfunction (a key risk factor for Alzheimer's...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186603/

データ提供：米国国立医学図書館（NLM）

3TC: A Potential Oasis in the Desert of Cognitive Decline

We're traversing the vast and complex landscape of brain aging, specifically investigating the challenges of age-related cognitive decline. This research explores the potential of a drug called 3TC, typically used to treat HIV infection, to combat cognitive dysfunction in aging. The researchers focused on the role of transposable elements (TEs), pieces of DNA that can move around the genome, in the aging process. They hypothesized that increased activity of TEs might contribute to cognitive decline, and that 3TC, by inhibiting the enzyme reverse transcriptase, could potentially mitigate these effects.

The researchers conducted a series of experiments using animal models, meticulously studying the effects of 3TC on cognitive function, neuroinflammation, and neuronal health. They discovered that 3TC, like a refreshing oasis in a scorching desert, showed promise in improving cognitive function, reducing inflammation, and preserving neuronal health.

3TC: A Potential Therapy for Age-Related Cognitive Decline

These findings suggest that 3TC could be a promising therapeutic agent for combating age-related cognitive decline, potentially leading to improved cognitive function and reduced risk of neurodegenerative diseases like Alzheimer's.

3TC: A Potential Oasis in the Desert of Alzheimer's

This research provides hope for individuals battling the challenges of cognitive decline associated with aging. It's a reminder that even in the vast and unforgiving desert of neurodegenerative diseases, there might be hidden oases offering potential pathways to better health.

Dr.Camel's Conclusion

This research shines a light on the potential of repurposing existing drugs for new therapeutic applications. 3TC, a drug already known for its effectiveness against HIV, might hold the key to combating cognitive decline and Alzheimer's, suggesting that innovation can emerge even in the most unexpected places.

Date :
  1. Date Completed 2023-05-17
  2. Date Revised 2023-06-27
Further Info :

Pubmed ID

36949552

DOI: Digital Object Identifier

PMC10186603

Related Literature

Article Analysis
・Effects of 3tc
SNS
PICO Info
in preparation
Languages

English

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