Efficacy and safety of lemborexant as an alternative drug for patients with insomnia taking gamma-aminobutyric acid-benzodiazepine receptor agonists or suvorexant.

Author: InamotoAtsuko, IwanamiAkira, KawaiKeita, OkinoKazumaro, SanadaKenji, SuzukiHirohisa, TomiokaHiroi

Paper Details 
Original Abstract of the Article :
Although gamma-aminobutyric acid-benzodiazepine (GABA-BZ) receptor agonists are used to treat insomnia, their long-term or high-dosage use causes adverse events. Nevertheless, evidence regarding the discontinuation and replacement of GABA-BZ receptor agonists with alternative agents is lacking. Suvo...See full text at original site
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引用元:
https://doi.org/10.1002/hup.2868

データ提供:米国国立医学図書館(NLM)

Lemborexant: A Potential Alternative for Insomnia Treatment

The pursuit of safe and effective treatments for insomnia is a constant endeavor in the field of sleep medicine. This study explores the potential of lemborexant as an alternative drug for patients with insomnia who are currently taking gamma-aminobutyric acid-benzodiazepine (GABA-BZ) receptor agonists or suvorexant. The researchers investigated the efficacy and safety of lemborexant as a replacement for these existing medications, aiming to address concerns about the long-term or high-dosage use of GABA-BZ receptor agonists.

The study provides evidence that lemborexant, an orexin receptor antagonist, shows promise as an alternative treatment for insomnia. The researchers suggest that lemborexant may offer a safer and more effective option for patients who are experiencing adverse effects from existing medications. However, the study emphasizes the need for further research to confirm its long-term efficacy and safety.

Lemborexant: A Potential Solution for Insomnia?

The study's findings offer hope for patients with insomnia, suggesting that lemborexant may provide a safer and more effective alternative to existing medications. The researchers emphasize the importance of carefully considering individual patient characteristics and potential risks when switching medications.

Health Implications and Lifestyle Considerations

The study highlights the importance of discussing treatment options with healthcare providers to determine the most appropriate approach for individual needs. The researchers recommend that patients who are experiencing adverse effects from their current insomnia medications should consult with their physician to explore potential alternatives, such as lemborexant. The study also underscores the importance of ongoing research to develop new and improved treatments for insomnia, addressing concerns about the long-term effects of existing medications.

Dr.Camel's Conclusion

The pursuit of a good night's sleep is a universal desire, much like the longing for a cool oasis in the midst of a scorching desert. This study explores the potential of lemborexant as a safer and more effective alternative for insomnia treatment, offering hope for those struggling to find restful slumber. The journey towards better sleep continues, guided by the pursuit of innovative solutions and a deep understanding of the complexities of sleep disorders.

Date :
  1. Date Completed 2023-05-08
  2. Date Revised 2023-05-09
Further Info :

Pubmed ID

36960814

DOI: Digital Object Identifier

10.1002/hup.2868

Related Literature

SNS
PICO Info
in preparation
Languages

English

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