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Lamivudine induced pure red cell aplasia and HIV-1 drug resistance-associated mutations: a case report.
Author: BikinesiTarisai, KakubuMireille A M, KatotoPatrick D M C
Original Abstract of the Article :
Adverse effects linked to antiretroviral therapy (ART) may contribute to poor adherence on the patient's side. Consequently, human immunodeficiency virus (HIV) drug resistance mutations could emerge, negatively impacting the body's immune system. Meanwhile, severe immunosuppression can lead to sever...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041944/
データ提供:米国国立医学図書館(NLM)
Lamivudine: A Rare Side Effect That Requires Vigilance
Antiretroviral therapy (ART) has transformed the lives of individuals living with HIV, but it can also lead to side effects, some of which are rare and potentially serious. This case report describes a patient who developed pure red cell aplasia (PRCA), a rare blood disorder characterized by a deficiency in red blood cell production, after starting ART with lamivudine. The report highlights the importance of monitoring patients for rare side effects associated with ART and adjusting treatment plans as needed.
Lamivudine-Induced PRCA: A Cautionary Tale
This case report underscores the need for careful monitoring of patients receiving lamivudine as part of their ART regimen. While PRCA is a rare side effect, it can have severe consequences. The report highlights the importance of early identification and prompt withdrawal of lamivudine in cases of suspected PRCA, enabling a more effective and safe treatment approach.
Individualized Care: A Key to Effective HIV Management
This case report serves as a reminder that each patient's response to ART can be unique. The importance of individualized care, including careful monitoring for rare side effects, is crucial for ensuring optimal treatment outcomes and minimizing potential risks.
Dr. Camel's Conclusion
Just like a camel navigating a vast and unpredictable desert, managing HIV infection can be a complex journey. This case report, like a warning sign along the path, highlights the importance of vigilance and personalized care in monitoring for rare side effects of ART. While lamivudine-induced PRCA is a rare event, it emphasizes the need for careful patient monitoring and a flexible approach to treatment.
Date :
- Date Completed n.d.
- Date Revised 2023-03-31
Further Info :
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English
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