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Original Abstract of the Article :
Pethidine (meperidine) can decrease labor pain-associated mother's hyperventilation and high cortisol-induced newborn complications. However, prenatal transplacentally acquired pethidine can cause side effects in newborns. High pethidine concentrations in the newborn brain extracellular fluid (bECF)...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://doi.org/10.1007/s13318-023-00823-x
データ提供：米国国立医学図書館（NLM）
Pethidine and the Newborn Brain: A Physiologically Based Pharmacokinetic Modeling Approach
The safety and efficacy of medications during pregnancy is a critical area of research. This study explores the use of pethidine (meperidine) during labor and its potential impact on the newborn. The research utilizes physiologically-based pharmacokinetic (PBPK) modeling to predict drug concentrations in the newborn's plasma, saliva, and brain extracellular fluid after intrauterine exposure. The study highlights the importance of understanding the transfer of drugs from mother to fetus and the potential risks associated with prenatal exposure to pethidine.
Pethidine and the Newborn: A Modeling Approach to Safety
The study demonstrates the power of PBPK modeling to predict drug levels in newborns after prenatal exposure. The model's ability to simulate drug concentrations in the brain extracellular fluid provides valuable insights into the potential risks associated with prenatal pethidine exposure. The study underscores the importance of carefully monitoring drug levels in both mother and newborn to minimize potential risks.
Navigating the Desert of Prenatal Drug Exposure
This research highlights the complexities of drug transfer during pregnancy and the importance of carefully considering potential risks to the newborn. It underscores the need for careful monitoring and management of drug levels in both mother and newborn to ensure optimal health outcomes. It's like navigating a desert, where every step requires careful consideration of potential hazards and the need for appropriate preparation and guidance.
Dr.Camel's Conclusion
This study highlights the importance of understanding the transfer of drugs from mother to fetus and the potential risks associated with prenatal exposure. It underscores the need for careful monitoring and management of drug levels in both mother and newborn to ensure optimal health outcomes. It's like navigating a desert, where every step requires careful consideration of potential hazards and the need for appropriate preparation and guidance.
Date :
- Date Completed 2023-05-15
- Date Revised 2023-05-15
Further Info :
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