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Viloxazine hydrochloride in narcolepsy: a preliminary report.

Author: GuilleminaultC, HayesB, MancusoJ, MitlerM, MontplaisirJ, PoirierG, SalvaM A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Viloxazine hydrochloride (100 mg/day) was well tolerated in narcoleptic subjects, particularly in elderly individuals. The drug effectively reduced REM sleep, cataplexy, and other symptoms associated with narcolepsy. While there was no objective evidence of increased alertness, patients reported fewer sleep attacks.
Paper Details　
Original Abstract of the Article :
Twenty-three narcoleptic subjects participated in a single-blind drug study with placebo-viloxazine hydrochloride (100 mg/day). One woman discontinued the study because of nausea and headaches during the treatment period. The remaining 22 subjects were polygraphically monitored during baseline, The ...See full text at original site
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引用元：
https://doi.org/10.1093/sleep/9.1.275

データ提供：米国国立医学図書館（NLM）

Viloxazine Hydrochloride: A Potential Oasis in the Desert of Narcolepsy

Narcolepsy, a neurological disorder characterized by excessive daytime sleepiness and other unusual symptoms, can be a debilitating condition.

This study, a single-blind drug trial, investigated the effects of viloxazine hydrochloride, a medication typically used for depression, on narcolepsy.

Viloxazine Hydrochloride: A Promising Treatment for Narcolepsy

The researchers found that viloxazine hydrochloride was generally well-tolerated by the participants, particularly in elderly subjects. The drug demonstrated a significant inhibitory effect on REM sleep, cataplexy, and other auxiliary symptoms associated with narcolepsy.

Potential Relief for Narcolepsy Patients

While viloxazine hydrochloride did not demonstrate a significant impact on alertness, the patients reported fewer sleep attacks. This suggests that viloxazine hydrochloride could potentially offer a new avenue for managing the symptoms of narcolepsy.

Dr. Camel's Conclusion

This study provides a promising glimpse into the potential of viloxazine hydrochloride for treating narcolepsy. While further research is needed to fully understand its effectiveness and optimize its use, this finding offers a beacon of hope for those struggling with this often-debilitating disorder.

Date :
  1. Date Completed 1986-06-12
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

3704453

DOI: Digital Object Identifier

10.1093/sleep/9.1.275

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Article Analysis
・Side Effects of viloxazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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