Brigatinib-associated autoimmune hepatitis: A case report.

Author: BuyuksimsekMahmut, CilTimucin, DumanBerna Bozkurt, KidiMehmet Mutlu, KoseciTolga, OgulAli, SumbulHilmi Erdem, TohumcuogluMert, YetisirAbdullah Evren

Paper Details 
Original Abstract of the Article :
INTRODUCTION: Brigatinib is a next-generation anaplastic lymphoma kinase (ALK) inhibitor that targets a wide variety of ALK mutations and ROS1 rearrangements. While pancreatic enzyme elevations due to brigatinib are well known, we wanted to present a case that caused liver toxicity. CASE REPORT: AL...See full text at original site
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引用元:
https://doi.org/10.1177/10781552231171322

データ提供:米国国立医学図書館(NLM)

Brigatinib and Autoimmune Hepatitis: A Case Study in a Dry Desert of Liver Health

The world of cancer treatment is constantly evolving, with new drugs offering hope for patients. This case report focuses on brigatinib, a drug that targets specific mutations associated with cancer. Brigatinib has shown promise in treating lung cancer, but, like a mirage in the desert, some unexpected side effects can emerge. This report explores the case of a patient who developed autoimmune hepatitis, a condition where the immune system attacks the liver, after receiving brigatinib. The patient experienced a significant elevation in liver enzymes, a sign of liver damage. The authors highlight the rarity of this side effect, emphasizing that it's crucial to be vigilant about monitoring liver function in patients receiving brigatinib.

The Unexpected Side Effects of Cancer Treatment: A Reminder to Stay Hydrated

This case report serves as a reminder that even with the most promising treatments, potential side effects are always a possibility. It's like a desert journey, where unexpected challenges can arise. The authors discuss how autoimmune hepatitis can be a rare but serious side effect of brigatinib. While brigatinib has shown efficacy in targeting cancer cells, it's important to be aware of its potential impact on liver function. This knowledge can help doctors and patients make informed decisions about treatment options.

Managing Liver Health: A Desert Oasis of Wellness

Autoimmune hepatitis can be a serious condition. It's essential to be aware of the potential side effects of medications, like brigatinib, and to monitor liver function regularly. If you experience any unusual symptoms, such as fatigue, jaundice, or abdominal pain, it's crucial to consult with a doctor immediately. It's like finding an oasis in the desert – it provides crucial respite and hydration.

Dr.Camel's Conclusion

While the desert of cancer treatment is full of hope, it's also a place of uncertainty. This case report illustrates the importance of careful monitoring and vigilance. Doctors and patients need to be prepared for unexpected side effects and act swiftly to address them. The search for new and effective cancer treatments continues, and we must always remember that the journey is as important as the destination.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-04-19
Further Info :

Pubmed ID

37073439

DOI: Digital Object Identifier

10.1177/10781552231171322

SNS
PICO Info
in preparation
Languages

English

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