Interleukins, growth factors, and transcription factors are key targets for gene therapy in osteoarthritis: A scoping review.

Author: GrisartJuliane, GuseKilian, HenrotinYves, LambertCécile, PlutizkiStanislav, UebelhoerMelanie

Paper Details 
Original Abstract of the Article :
Osteoarthritis (OA) is the most common degenerative joint disease, characterized by a progressive loss of cartilage associated with synovitis and subchondral bone remodeling. There is however no treatment to cure or delay the progression of OA. The objective of this manuscript was to provide a scopi...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106745/

データ提供:米国国立医学図書館(NLM)

Gene Therapy: A Potential Oasis in the Desert of Osteoarthritis

Osteoarthritis, a degenerative joint disease, is a common ailment that affects millions around the globe, leaving many individuals with chronic pain and limited mobility. It's like a slow-burning fire, gradually eroding the cartilage that cushions our joints. Gene therapy has emerged as a potential beacon of hope in the desolate landscape of osteoarthritis treatment. This study conducted a comprehensive review of preclinical and clinical studies exploring the therapeutic potential of gene therapy for osteoarthritis. The authors examined a diverse array of potential targets, including interleukins, growth factors, and transcription factors, all playing intricate roles in the complex tapestry of joint degeneration.

Gene Therapy: A Promising Strategy for Repairing Damaged Joints

Gene therapy holds immense promise for osteoarthritis treatment, like a desert bloom that brings life to a barren landscape. This review suggests that gene therapy, by precisely targeting the underlying cellular mechanisms, could provide a potent approach for combating osteoarthritis. It may offer a way to regenerate damaged cartilage, alleviate inflammation, and ultimately improve joint function.

A Glimpse into the Future of Osteoarthritis Treatment

This study provides a valuable roadmap for future research in gene therapy for osteoarthritis. By highlighting the potential therapeutic targets and the promising results from existing studies, it offers a glimmer of hope for millions who suffer from this debilitating disease. It's important to note that gene therapy is still in its early stages of development, but this review provides a compelling case for continued research and clinical trials. The future of osteoarthritis treatment may well lie in the hands of gene therapy, offering the possibility of restoring mobility and alleviating pain for those affected by this debilitating disease.

Dr. Camel's Conclusion

Gene therapy, like a mirage in the desert, offers a tantalizing glimpse of a potential cure for osteoarthritis. This review highlights the promising therapeutic potential of gene therapy in addressing the complex cellular processes involved in joint degeneration. The research community, like explorers searching for a hidden oasis, must continue to investigate and refine these promising strategies to alleviate the suffering caused by osteoarthritis.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-04-21
Further Info :

Pubmed ID

37077668

DOI: Digital Object Identifier

PMC10106745

Related Literature

SNS
PICO Info
in preparation
Languages

English

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