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Understanding the molecular mechanisms of statin pleiotropic effects.

Author: GermanCharles A, LiaoJames K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Statins are the mainstay of pharmacotherapy for preventing atherosclerotic cardiovascular disease. They lower LDL-C by inhibiting the rate-limiting step in cholesterol biosynthesis and increasing LDL receptor expression. While statins are effective in reducing major adverse cardiovascular events, some research suggests they may have additional "pleiotropic" effects, such as improving plaque stability, reducing inflammation, and improving endothelial function. However, other studies suggest potential harmful effects, including muscle damage, diabetes, and cognitive decline. Newer non-statin LDL-C lowering therapies challenge the statin pleiotropy theory, making further research crucial to understanding the full spectrum of statin effects.
Paper Details　
Original Abstract of the Article :
Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic cardiovascular disease. These medications not only reduce low-density lipoprotein cholesterol (LDL-C) via inhibition of 3-hydroxy-3-methylglutarate attached to CoA reductase, the key rate-limiting step in the ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119541/

データ提供：米国国立医学図書館（NLM）

Exploring the Pleiotropic Effects of Statins: Beyond Cholesterol Reduction

Statins, a mainstay in cardiovascular disease prevention, are like the trusty camels of the pharmaceutical world. They diligently carry the load of lowering cholesterol, but recent investigations suggest they might have other, less obvious talents – pleiotropic effects. This research dives deep into the multifaceted nature of statins, examining their potential benefits beyond cholesterol management. The authors meticulously review the literature and analyze the mechanisms underlying these pleiotropic effects, highlighting both their potential for improving plaque stability, reducing inflammation, and boosting vascular function, as well as potential risks like muscle-related side effects and cognitive decline.

Balancing the Benefits and Risks of Statins

While the traditional focus of statins has been on lowering cholesterol, this research emphasizes the need to consider their broader effects on the body. The findings suggest that statins might play a more intricate role in cardiovascular health, potentially offering additional benefits, but also carrying the possibility of unintended consequences. This understanding is crucial for making informed decisions about statin therapy.

Navigating the Shifting Sands of Statin Treatment

This research underscores the dynamic nature of medical knowledge. As our understanding of statins evolves, the landscape of cardiovascular treatment is likely to change as well. This research serves as a reminder to always be mindful of the potential benefits and risks of any medication, including those that are widely prescribed. It's crucial to have open and honest conversations with your healthcare provider about your individual needs and preferences.

Dr.Camel's Conclusion

Statins, like the shifting dunes of the desert, are complex and multifaceted. This research encourages us to explore their effects with a discerning eye, recognizing both their potential for improving cardiovascular health and the need for careful consideration of potential risks.

Date :
  1. Date Completed 2023-05-15
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

37084080

DOI: Digital Object Identifier

PMC10119541

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