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Intestinal permeability and its significance in psychiatric disorders - A narrative review and future perspectives.

Author: Gawlik-KotelnickaOliwia, WasiakJakub

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review examines the link between increased intestinal permeability and psychiatric illnesses. It highlights the "leaky gut" syndrome and its potential role in mood disorders, schizophrenia, alcohol dependence, and other conditions. Possible mechanisms include chronic inflammation, disruption of the blood-brain barrier, and altered neurotransmitter levels. Further research may lead to earlier diagnosis and targeted treatments.
Paper Details　
Original Abstract of the Article :
The topic of increased intestinal permeability and its impact on the human body is increasingly being addressed by researchers. It is associated with disruption of the intestinal barrier, leading to the "leaky gut" syndrome. This can be assessed by classical methods, determining the concentration of...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.bbr.2023.114459

データ提供：米国国立医学図書館（NLM）

Exploring the Leaky Gut-Brain Connection in Psychiatric Disorders

The role of intestinal permeability, or 'leaky gut', in the development of psychiatric disorders is a growing area of research. This narrative review examines the connection between increased intestinal permeability and a range of mental health conditions, including mood disorders, schizophrenia, alcohol dependence, and anxiety disorders. The review explores potential mechanisms by which a leaky gut could impact brain function, including inflammation, disruption of the blood-brain barrier, and altered neurotransmitter levels.

Unlocking the Secrets of the Gut-Brain Axis

This review sheds light on the complex interplay between the gut and the brain, highlighting the potential role of intestinal permeability in the development of psychiatric disorders. It's like exploring a vast desert, uncovering hidden pathways and connections that influence the delicate balance of the human body. This research encourages further exploration of the gut-brain axis to develop new therapeutic approaches for these complex conditions.

Implications for Mental Health Treatment

The findings of this review have significant implications for the understanding and treatment of psychiatric disorders. It suggests that targeting gut health may be a promising strategy for addressing mental health conditions, potentially leading to more effective and personalized therapies. It's like finding a hidden oasis in the desert, offering a fresh source of hope and potential solutions.

Dr.Camel's Conclusion

The journey towards understanding the complex interplay between the gut and the brain is a continuous exploration, akin to a camel's tireless trek through the desert. This review highlights the potential role of intestinal permeability in psychiatric disorders, opening up new avenues for research and treatment. It's a reminder that even in the most complex and enigmatic landscapes, persistence and curiosity can lead to groundbreaking discoveries that enhance human health and well-being.
Date :
  1. Date Completed 2023-05-15
  2. Date Revised 2023-05-16
Further Info :

Pubmed ID

37121278

DOI: Digital Object Identifier

10.1016/j.bbr.2023.114459

SNS
PICO Info
in preparation
Languages

English

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