Abaloparatide prevents immobilization-induced cortical but not trabecular bone loss after spinal cord injury.

Author: BaumanWilliam A, CardozoChristopher P, PanJiangping, SahbaniKarim, TawfeekHesham A, ZaidiMone

Paper Details 
Original Abstract of the Article :
Spinal cord injury (SCI) causes severe and resistant sublesional disuse bone loss. Abaloparatide, a modified parathyroid hormone related peptide, is an FDA approved drug for treatment of severe osteoporosis with potent anabolic activity. The effects of abaloparatide on SCI-induced bone loss remain u...See full text at original site
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引用元:
https://doi.org/10.1096/fj.202300109RR

データ提供:米国国立医学図書館(NLM)

Abaloparatide: A Potential Boon for Spinal Cord Injury-Related Bone Loss

Spinal cord injury (SCI) is a devastating condition that can lead to severe bone loss, making it a challenging area of research. This study explores the potential of abaloparatide, an FDA-approved drug for osteoporosis, to mitigate bone loss after SCI. Researchers conducted a comprehensive study using a mouse model to evaluate the effects of abaloparatide on bone loss following SCI. This research serves as a crucial stepping stone in the search for effective treatments to address the bone loss associated with SCI.

Abaloparatide Shows Promise in Protecting Cortical Bone

The study found that abaloparatide treatment significantly attenuated SCI-induced loss in cortical bone thickness, demonstrating its protective effect on this specific type of bone. This finding holds immense promise for improving bone health and reducing the severity of bone loss in individuals with SCI.

Maintaining Bone Strength After Spinal Cord Injury

This research sheds light on the potential of abaloparatide as a therapeutic agent for mitigating bone loss in patients with SCI. It underscores the importance of proactive management of bone health in individuals who have experienced SCI.

Dr. Camel's Conclusion

Just as the desert winds shape the dunes, SCI presents a formidable challenge to bone health. This study reveals that abaloparatide holds promise in mitigating cortical bone loss after SCI, offering hope for improved bone health and a better quality of life for those affected by this debilitating injury.

Date :
  1. Date Completed 2023-05-25
  2. Date Revised 2023-05-30
Further Info :

Pubmed ID

37219516

DOI: Digital Object Identifier

10.1096/fj.202300109RR

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SNS
PICO Info
in preparation
Languages

English

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