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Calcium carbonate nanoparticles tumor delivery for combined chemo-photodynamic therapy: Comparison of local and systemic administration.

Author: AgeevEduard I, BrodskaiaAleksandra, DarwishAya, MitusovaKsenia A, MuslimovAlbert R, RogovaAnna, TiminAlexander S, YakubovaAnastasiya A, ZyuzinMikhail V

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compares the therapeutic efficiency and side effects of delivering multiple therapeutic agents with nanoparticles (NPs) through intravenous and intratumoral injections. The study found that intratumoral injection resulted in significantly higher tumor accumulation of NPs, leading to improved tumor inhibition compared to intravenous injection.
Paper Details　
Original Abstract of the Article :
The use of nanoparticles (NPs) as delivery vehicles for multiple drugs is an intensively developing area. However, the success of NPs' accumulation in the tumor area for efficient tumor treatment has been recently questioned. Distribution of NPs in a laboratory animal is mainly related to the admini...See full text at original site
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引用元：
https://doi.org/10.1016/j.jconrel.2023.06.012

データ提供：米国国立医学図書館（NLM）

Calcium Carbonate Nanoparticles for Cancer Treatment

This research explores the use of calcium carbonate (CaCO3) nanoparticles as delivery vehicles for combined chemo-photodynamic therapy (PDT) of B16-F10 melanoma tumors. The researchers investigated the therapeutic efficiency and side effects of delivering multiple therapeutic agents with CaCO3 nanoparticles using both intravenous and intratumoral injections. Their findings demonstrate the effectiveness of this approach in inhibiting tumor growth, with both administration routes showing significant anti-tumor effects and negligible toxicity.

Nanoparticle-Based Delivery for Cancer Therapy

This study highlights the potential of nanoparticles as targeted delivery vehicles for cancer therapy. The researchers' findings suggest that CaCO3 nanoparticles effectively deliver both chemotherapeutic drugs and photosensitizers to the tumor site, leading to significant tumor inhibition. This research contributes to the growing field of nanomedicine and its application in cancer treatment.

Potential for Improved Cancer Treatments

This research opens new possibilities for improving cancer treatments. The researchers' findings suggest that nanoparticle-based delivery could enhance the efficacy and reduce the side effects of conventional therapies. This research inspires continued exploration of nanotechnology as a tool for developing more targeted and effective cancer treatments.

Dr.Camel's Conclusion

This study offers a promising glimpse into the future of cancer treatment. The researchers' innovative use of CaCO3 nanoparticles as delivery vehicles for combined chemo-photodynamic therapy demonstrates the potential of nanotechnology to revolutionize cancer treatment. This research is a beacon of hope, showcasing the power of scientific ingenuity in addressing the complex challenge of cancer.
Date :
  1. Date Completed 2023-07-14
  2. Date Revised 2023-07-18
Further Info :

Pubmed ID

37315692

DOI: Digital Object Identifier

10.1016/j.jconrel.2023.06.012

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・Side Effects of calcium carbonate
SNS
PICO Info
in preparation
Languages

English

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