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Exploring the interactions of antihistamine with retinoic acid receptor beta (RARB) by molecular dynamics simulations and genome-wide meta-analysis.

Author: GoodeMicah A, KimMinjae J, KulkarniVishnutheertha, SivesindTorunn E

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study explores the potential of antihistamines as a treatment for Kaposi sarcoma (KS), a common AIDS-related cancer. Using in-silico methods, the study identifies bepotastine and hydroxyzine as promising candidates for further research, potentially offering a safer alternative to the current treatment, 9-cis-retinoic acid.
Paper Details　
Original Abstract of the Article :
Kaposi sarcoma (KS) is one of the most common AIDS-related malignant neoplasms, which can leave lesions on the skin among HIV patients. These lesions can be treated with 9-cis-retinoic acid (9-cis-RA), an endogenous ligand of retinoic acid receptors that has been FDA-approved for treatment of KS. Ho...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/37331258

データ提供：米国国立医学図書館（NLM）

Exploring Antihistamines as Potential Treatments for Kaposi Sarcoma

Kaposi sarcoma (KS), a type of cancer associated with HIV infection, is a challenging disease to treat. This study explores the potential of antihistamines, commonly used for allergies, as a novel treatment for KS. The researchers utilized molecular dynamics simulations and a genome-wide meta-analysis to investigate the interactions between antihistamines and retinoic acid receptor beta (RARβ), a protein involved in cell growth and differentiation. Their findings suggest that certain antihistamines, such as bepotastine and hydroxyzine, might activate RARβ, potentially offering a new therapeutic avenue for KS.

Antihistamines as a New Weapon in the Fight Against KS

This study offers a fresh perspective on KS treatment, suggesting that over-the-counter antihistamines could potentially be repurposed for this disease. The research opens up a new avenue for exploring the therapeutic potential of readily available medications, potentially offering a less-invasive and more affordable treatment option. This is a significant finding in the desert of KS research, potentially leading to new and effective treatments.

Repurposing Antihistamines for Cancer Treatment

This study highlights the exciting potential of drug repurposing, exploring the use of existing medications for new therapeutic applications. The researchers' findings suggest that antihistamines might hold promise for treating KS, paving the way for further investigation into the potential of these readily available drugs for combating cancer.

Dr.Camel's Conclusion

This study explores the fascinating possibility of repurposing antihistamines for the treatment of Kaposi sarcoma. The research suggests that certain antihistamines might activate RARβ, a protein involved in cell growth and differentiation, potentially offering a new and less invasive treatment option. This research is a beacon of hope in the desert of KS research, potentially leading to new and effective therapies for this challenging disease.

Date :
  1. Date Completed 2023-08-14
  2. Date Revised 2023-10-03
Further Info :

Pubmed ID

37331258

DOI: Digital Object Identifier

NIHMS1910292

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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