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The opposite effect of tapinarof between IMQ and IL-23 induced psoriasis mouse models.

Author: HanRuomei, HochgernerMathias, LiHui, TianXiaoxue, WangJiucun, XiaJingjing, ZhuXingyu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tapinarof, an aryl hydrocarbon receptor (AHR) ligand, has opposite effects on two different psoriasis mouse models. In the imiquimod (IMQ) model, tapinarof reduced inflammation and improved psoriatic dermatitis. However, in the IL-23 injection model, tapinarof aggravated the disease, suggesting that tapinarof may have varying effects on different types of psoriasis.
Paper Details　
Original Abstract of the Article :
Tapinarof is an aryl hydrocarbon receptor (AHR) ligand which is used to treat plaque psoriasis in adults. However, the underlying mechanism is not yet fully understood. In this study, we applied two of the most studied psoriasis mouse models: topical application of imiquimod (IMQ) and subcutaneous i...See full text at original site
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引用元：
https://doi.org/10.1111/exd.14862

データ提供：米国国立医学図書館（NLM）

Tapinarof: A Double-Edged Sword in Psoriasis Treatment

Psoriasis, a chronic inflammatory skin condition, can be a significant challenge for patients. This study investigates the effects of tapinarof, an aryl hydrocarbon receptor (AHR) ligand used to treat psoriasis, in two different mouse models of the disease. The authors explore the potential for tapinarof to have varied effects depending on the underlying mechanisms of psoriasis.

Tapinarof: A Complex Response in Psoriasis Treatment

The research reveals that tapinarof can have opposite effects in different psoriasis models. The study found that tapinarof effectively ameliorated imiquimod-induced psoriatic dermatitis, but it aggravated IL-23-induced psoriasis, suggesting that its efficacy might be dependent on the specific inflammatory pathways involved in the disease.

Navigating the Complexities of Psoriasis Treatment

This study highlights the importance of considering the underlying mechanisms of psoriasis when selecting treatment options. Just as a desert traveler needs to adapt their route to the terrain, clinicians must tailor treatment approaches to the specific characteristics of each patient's psoriasis. This research emphasizes the need for a personalized approach to psoriasis management, considering the diverse pathways that contribute to the disease.

Dr.Camel's Conclusion

This research reminds us that the path to effective treatment for psoriasis is not always straightforward. The complex nature of the disease requires a nuanced understanding of the underlying mechanisms involved. This research underscores the importance of continued research to unravel the complexities of psoriasis and develop more targeted and effective therapies.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-06-23
Further Info :

Pubmed ID

37350230

DOI: Digital Object Identifier

10.1111/exd.14862

Related Literature

Article Analysis
・Effects of tapinarof topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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