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Efficacy and safety of macitentan for pulmonary hypertension: A meta-analysis.

Author: DuDan, YuanYa-Dong

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Macitentan is effective and safe for the treatment of pulmonary hypertension (PH). It significantly reduced pulmonary vascular resistance (PVR), cardiac index (CI), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with PH. The most common side effects were headache, anemia, and bronchitis.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Our purpose of this study is to evaluate the effect and safety of macitentan in the treatment of pulmonary hypertension (PH). METHODS: We retrieved the safety and efficacy of macitentan treatment for PH using PubMed, the Cochrane Library, EMBASE databases and clinicaltrials.gov. The C...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632077/

データ提供：米国国立医学図書館（NLM）

Macitentan for Pulmonary Hypertension: A Meta-Analysis

Pulmonary hypertension (PH) is a serious condition that affects the heart and lungs. This study evaluates the effectiveness and safety of macitentan, a medication used to treat PH. The researchers conducted a meta-analysis of multiple studies to assess the impact of macitentan on various PH parameters and to identify potential side effects.

Macitentan Offers Hope in the Desert of Pulmonary Hypertension

The meta-analysis reveals that macitentan demonstrates significant efficacy in reducing pulmonary vascular resistance, improving cardiac index, and lowering NT-proBNP levels, a biomarker associated with heart strain. It’s like discovering a new oasis in the desert of pulmonary hypertension, offering a source of relief and potential for improved cardiovascular health. The study highlights the potential of macitentan as a valuable treatment option for patients with PH.

Navigating the Complexities of PH Treatment

The study acknowledges that further research is needed to confirm the long-term effectiveness of macitentan on specific outcomes, such as mortality. It's like exploring a vast and complex desert, where continued exploration and scientific investigation are crucial to uncovering the full potential of this treatment. The study highlights the need for ongoing research and careful monitoring to optimize the use of macitentan in managing PH.

Dr.Camel's Conclusion

The meta-analysis of macitentan for pulmonary hypertension provides encouraging evidence of its effectiveness and safety. The study suggests that macitentan holds promise as a valuable treatment option for patients with PH, offering potential for improved cardiovascular health and quality of life. It's like discovering a new path in the desert of pulmonary hypertension, offering a more effective and well-tolerated approach for managing this challenging condition. However, further research is crucial to fully understand the long-term benefits and risks associated with macitentan therapy.
Date :
  1. Date Completed 2023-11-10
  2. Date Revised 2023-11-10
Further Info :

Pubmed ID

37427711

DOI: Digital Object Identifier

PMC10632077

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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