Therapeutic cyproheptadine regimen in serotonin syndrome: Complications after cardiovascular surgery.

Author: HaqueMahfujul, JudgeRamzan, LeeJoseph, NagyAhmed, NasirAishah

Paper Details 
Original Abstract of the Article :
Serotonin syndrome can be a life-threatening condition that occurs from the overactivity of serotonin in the central nervous system. This report describes the use of cyproheptadine for the management of serotonin syndrome in a patient taking fluoxetine and bupropion, who received methylene blue for ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354353/

データ提供:米国国立医学図書館(NLM)

Therapeutic Management of Serotonin Syndrome: A Case Report Highlighting Cyproheptadine's Role

The field of [pharmacology] is dedicated to understanding the complex interactions between medications and the human body. This case report examines the successful management of [serotonin syndrome] in a patient who developed this life-threatening condition following a [coronary artery bypass graft surgery].

The researchers describe the case of a 61-year-old female who was taking [fluoxetine] and [bupropion] preoperatively. During and after surgery, she received multiple doses of [methylene blue] to treat [vasoplegia syndrome]. However, the patient subsequently developed symptoms consistent with serotonin syndrome, likely due to a drug-drug interaction. The researchers successfully treated the serotonin syndrome using [cyproheptadine] and supportive care. The case report highlights the importance of recognizing the signs and symptoms of serotonin syndrome and promptly initiating appropriate treatment. It also suggests a potential dosing regimen for cyproheptadine, which can be used as a guide for future cases.

The Importance of Understanding Drug Interactions and Serotonin Syndrome

This case report underscores the critical importance of understanding potential drug interactions and recognizing the signs and symptoms of serotonin syndrome. Healthcare professionals must be vigilant in assessing patients' medication history and closely monitoring for any signs of this potentially life-threatening condition.

The Value of Case Reports in Medical Practice

Case reports play a valuable role in medical practice by providing insights into rare conditions and potential treatment approaches. This case report contributes to the growing body of knowledge on the management of serotonin syndrome, offering a real-world example of successful treatment using cyproheptadine.

Dr.Camel's Conclusion

Just as the desert can be a place of unexpected challenges, the world of pharmacology is filled with intricate interactions that can sometimes lead to unforeseen consequences. This case report offers a valuable lesson in understanding the potential for drug-drug interactions and the importance of recognizing serotonin syndrome. It's a reminder that vigilance and prompt intervention are key to ensuring patient safety and providing effective care.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-20
Further Info :

Pubmed ID

37476598

DOI: Digital Object Identifier

PMC10354353

Related Literature

SNS
PICO Info
in preparation
Languages

English

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