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ADT-OH synergistically enhanced the antitumor activity of celecoxib in human colorectal cancer cells.

Author: CaiFangfang, HuaZi-Chun, LiPing, MaHailin, SunHuisong, TanYuanhao, WangXiaoyang, XuHuangru, XuJiaqi, ZhuangHongqin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the synergistic effect of 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT-OH) and celecoxib on human colorectal cancer HCT116 cells. The combination therapy synergistically inhibited cell proliferation and migration, altered cell cycle and cytoskeleton, increased intracellular reactive oxygen species (ROS), and promoted cell apoptosis. In vivo studies also showed excellent antitumor therapeutic effect without apparent toxicity. This study provides a reasonable combination strategy of low-dose ADT-OH and celecoxib in the preclinical application of colorectal cancer.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Colorectal cancer is one of the most prevalent cancers in the world, but the research on its prevention, early diagnosis and treatment is still a major challenge in clinical oncology. Thus, there is a pressing requirement to find effective strategies to improve the survival of colon canc...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501245/

データ提供：米国国立医学図書館（NLM）

Combating Colorectal Cancer: A Synergy for Survival

The fight against colorectal cancer is a long and winding desert trek, my friend. This research explores a promising oasis in this fight! This study delves into the realm of colorectal cancer treatments, a challenging field where finding effective strategies to improve survival rates is paramount. The researchers employed a clever strategy, combining two drugs - celecoxib and ADT-OH - to see if they could work together to effectively combat the disease. Their findings suggest that this combination could be a valuable weapon in our arsenal against colorectal cancer.

A Powerful Partnership: Synergistic Effects for Enhanced Cancer Treatment

The study revealed that combining celecoxib and ADT-OH not only inhibited the growth of colorectal cancer cells, but also hindered their ability to spread, a critical factor in cancer progression. They observed this effect in human colorectal cancer HCT116 cells, and even tested it in live animals (in vivo) with positive results.

A New Frontier for Colorectal Cancer Treatment

This research offers a glimmer of hope for colorectal cancer patients, paving the way for a new treatment strategy. The combination therapy might provide a gentler approach, potentially leading to fewer side effects for patients. However, as a good doctor, I always emphasize that further research is needed to fully assess the long-term effects and ensure safety before this approach is widely adopted in clinical practice.

Dr.Camel's Conclusion

This study, like a beacon in the vast desert of cancer research, points towards a potential synergistic solution for colorectal cancer treatment. Combining ADT-OH and celecoxib demonstrates a promising approach to combat this disease, potentially leading to improved survival rates. However, as with all scientific discoveries, further investigation and clinical trials are necessary to fully explore its potential and ensure the safety of this combination therapy for patients.

Date :
  1. Date Completed 2023-09-15
  2. Date Revised 2023-09-16
Further Info :

Pubmed ID

37492969

DOI: Digital Object Identifier

PMC10501245

Related Literature

Article Analysis
・Side Effects of celecoxib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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