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Sabin polio virus protein 1 (VP1) evolution in patients with acute flaccid paralysis from 2010 to 2016 in Uganda.

Author: BakamutumahoBarnabas, BirungiMolly, BukenyaHenry, BwogiJosephine, ByabamazimaCharles Rutebarika, DhatemwaRajab, ElikuJames Peter, KakoozaProscovia, NamuwulyaProssy, NantezaMary Bridget, TibanagwaMayi, TushabePhionah

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study characterized mutations in the VP1 protein of polioviruses identified from stool specimens of patients with acute flaccid paralysis (AFP). The findings could contribute to efforts to mitigate the risk of vaccine-derived polioviruses and develop safer vaccines.
Paper Details　
Original Abstract of the Article :
Acute flaccid paralysis (AFP) is a rare side effect of the oral polio vaccine but can be associated with outbreaks and permanent disability in patients harboring circulating vaccine-derived polioviruses (cVDPVs). With the advancement of polio abolition in a glimpse, cVDPVs are causing outbreaks and ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399017/

データ提供：米国国立医学図書館（NLM）

Tracking the Evolution of Poliovirus in Patients with Acute Flaccid Paralysis

The fight against polio, a relentless battle against a crippling disease, is far from over. This study investigates the evolution of Sabin poliovirus protein 1 (VP1) in patients with acute flaccid paralysis (AFP) in Uganda, a country still grappling with the threat of polio outbreaks. The researchers analyzed the VP1 sequences of polioviruses identified from stool specimens of AFP patients, seeking to understand the genetic changes that contribute to the emergence of circulating vaccine-derived polioviruses (cVDPVs).

Understanding the Evolution of Poliovirus

The study highlights the importance of monitoring the genetic evolution of polioviruses to understand the emergence and spread of cVDPVs. It provides valuable insights into the genetic changes associated with AFP, particularly the VP1 amino acid substitutions that could be linked to viral transmission and the emergence of cVDPVs.

A Vital Tool for Polio Eradication

This research contributes to the global efforts to eradicate polio by providing valuable data on the evolution of polioviruses in AFP patients. It emphasizes the importance of ongoing surveillance and genetic monitoring to identify and track cVDPVs, enabling timely interventions to prevent outbreaks and protect vulnerable populations.

Dr.Camel's Conclusion

This research sheds light on the complex evolution of poliovirus, a reminder of the ongoing battle against this debilitating disease. By carefully tracking the genetic changes of polioviruses in AFP patients, researchers can gain valuable insights into the emergence and spread of cVDPVs, paving the way for more effective strategies to combat this threat and ultimately eradicate polio.

Date :
  1. Date Completed 2023-08-04
  2. Date Revised 2023-12-14
Further Info :

Pubmed ID

37533043

DOI: Digital Object Identifier

PMC10399017

Related Literature

Article Analysis
・Effects of polio vaccine
SNS
PICO Info
in preparation
Languages

English

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