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The Effect of Topical Nifedipine versus Diltiazem on the Acute Anal Fissure: A Randomized Clinical Trial.

Author: MansouriMasoume, Mohammadi GanjaroudiNegar, Momayez SanatZahra

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Topical nifedipine was more effective than topical diltiazem in treating acute anal fissure, with a higher remission rate (77.4% vs 54%) and faster pain relief. However, both treatments had similar side effects and recurrence rates.
Paper Details　
Original Abstract of the Article :
<b>Background:</b> The anal fissure is one of the most common anorectal diseases that is associated with reduced quality of life and productivity loss. We aimed to compare the efficacy of topical nifedipine and diltiazem for the treatment of acute anal fissure (AAF). <b>Methods:</b> This single-bli...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404091/

データ提供：米国国立医学図書館（NLM）

Comparing Topical Treatments for Acute Anal Fissure: Nifedipine vs. Diltiazem

Navigating the complexities of anorectal diseases is like traversing a sandy desert, filled with discomfort and challenges. This research focuses on the effectiveness of topical nifedipine and diltiazem in treating acute anal fissure (AAF), a prevalent condition that significantly impacts quality of life. The study, conducted using a randomized controlled trial, compares the efficacy of these two treatments in achieving fissure remission, alleviating pain, and minimizing side effects. The results suggest that topical nifedipine may offer a more rapid and effective treatment option for AAF compared to diltiazem.

Topical Nifedipine: A Potential Oasis for Acute Anal Fissure

The study reveals that topical nifedipine demonstrates a significantly higher remission rate compared to topical diltiazem in the treatment of AAF. Additionally, nifedipine is associated with earlier pain relief, providing a more rapid resolution of symptoms for patients. While both medications have comparable side effect profiles and recurrence rates, the study highlights the potential benefits of topical nifedipine for treating AAF.

Finding Relief in the Desert of Anal Fissure: Practical Takeaways

The research offers valuable insights for individuals seeking effective treatment for AAF. The study suggests that topical nifedipine may offer a more rapid and effective solution compared to diltiazem. It is important to consult with a healthcare professional to determine the most appropriate treatment option based on individual needs.

Dr. Camel's Conclusion

This study provides a valuable comparison of two topical treatments for acute anal fissure, offering a roadmap for navigating this challenging condition. The findings suggest that topical nifedipine may provide a faster path to relief, but it is essential to consult with a healthcare professional for personalized guidance.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-08-08
Further Info :

Pubmed ID

37546514

DOI: Digital Object Identifier

PMC10404091

Related Literature

Article Analysis
・Side Effects of nifedipine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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