Paper Details

  1. Home
  2. Paper Details

Anti-Diabetic Activity of Glycyrrhetinic Acid Derivatives FC-114 and FC-122: Scale-Up, In Silico, In Vitro, and In Vivo Studies.

Author: Aranda-BarradasMaría E, Cortés-BenítezFrancisco, Duperou-LunaPaulina, Fuerte-GómezTeresa, González-AndradeMartin, Matadamas-MartínezFélix, Mercado-MárquezCrisóforo, Miranda-CastroSusana Patricia, Palacios-EspinosaJuan Francisco, Pérez-VillanuevaJaime, Solís-DomínguezLuz Cassandra, Álvarez-AlmazánSamuel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Two semisynthetic glycyrrhetinic acid (GA) derivatives, FC-114 and FC-122, exhibit potent inhibitory activity against Protein Tyrosine Phosphatase 1B (PTP1B) and α-glucosidase enzymes. FC-122, a dual inhibitor, shows promising anti-diabetic activity in vivo, improving insulin levels and reducing LDL and total cholesterol levels. Both derivatives are safe and demonstrate better anti-diabetic activity than acarbose.
Paper Details　
Original Abstract of the Article :
Type 2 diabetes (T2D) is one of the most common diseases and the 8th leading cause of death worldwide. Individuals with T2D are at risk for several health complications that reduce their life expectancy and quality of life. Although several drugs for treating T2D are currently available, many of the...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454726/

データ提供：米国国立医学図書館（NLM）

Glycyrrhetinic Acid Derivatives: A Natural Approach to Fighting Diabetes

Type 2 diabetes (T2D), a chronic condition affecting millions worldwide, is a significant public health concern. This study explores the potential of two glycyrrhetinic acid (GA) derivatives, FC-114 and FC-122, as anti-diabetic agents. Researchers conducted in silico, in vitro, and in vivo studies to assess the compounds' activity against key enzymes involved in glucose metabolism. The study's findings suggest that these GA derivatives possess potent anti-diabetic properties, potentially offering a natural and effective alternative to conventional diabetes medications.

Harnessing the Power of Natural Compounds

The study highlights the promising anti-diabetic potential of FC-114 and FC-122, two GA derivatives. These compounds demonstrated potent inhibitory activity against PTP1B and α-glucosidase, key enzymes involved in glucose metabolism. The study's findings suggest that these natural compounds could potentially offer a safe and effective approach to managing T2D, reducing reliance on synthetic medications and their associated side effects.

Living a Healthier Life with Diabetes

If you've been diagnosed with T2D, it's crucial to work closely with your healthcare provider to manage your condition effectively. This includes making lifestyle changes, such as adopting a healthy diet, engaging in regular physical activity, and monitoring your blood sugar levels. Don't hesitate to discuss your treatment options with your doctor, exploring both conventional and alternative therapies to find the best approach for you.

Dr. Camel's Conclusion

This study offers a fascinating glimpse into the potential of natural compounds, like glycyrrhetinic acid derivatives, to address the growing challenge of T2D. The research's focus on developing safer and more effective therapies underscores the importance of exploring natural resources for medicinal purposes. As a researcher who believes in the power of nature's bounty, I applaud this study's efforts to find natural solutions for this critical health condition.
Date :
  1. Date Completed 2023-08-28
  2. Date Revised 2023-08-29
Further Info :

Pubmed ID

37628991

DOI: Digital Object Identifier

PMC10454726

Related Literature

Article Analysis
・Side Effects of acarbose
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.