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Effects of Quinine on the Glycaemic Response to, and Gastric Emptying of, a Mixed-Nutrient Drink in Females and Males.

Author: BitarafanVida, Feinle-BissetChristine, HorowitzMichael, LangeKylie, MohammadpourZinat, RehfeldJens Frederik, RezaiePeyman, RoseBraden David

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Intraduodenal quinine may modulate glucoregulatory functions, resulting in glucose lowering in both healthy men and women. However, the glucose-lowering effect appears to be greater in women than men, without significant differences in gastrointestinal function.
Paper Details　
Original Abstract of the Article :
Intraduodenal quinine, in the dose of 600 mg, stimulates glucagon-like peptide-1 (GLP-1), cholecystokinin and insulin; slows gastric emptying (GE); and lowers post-meal glucose in men. Oral sensitivity to bitter substances may be greater in women than men. We, accordingly, evaluated the dose-related...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459881/

データ提供：米国国立医学図書館（NLM）

Quinine's Effects on Glucose Regulation: A Tale of Two Sexes

In the vast desert of metabolic research, we often encounter intriguing interactions between medications and various bodily functions. This study, like a curious camel exploring an oasis, examined the dose-related effects of quinine on glucose regulation and gastric emptying in both men and women. The researchers discovered that quinine can modulate glucose regulation, with women experiencing greater glucose-lowering effects than men, despite similar gastrointestinal impacts. This finding offers a fascinating glimpse into the complex interplay of sex-specific differences in drug responses.

Quinine: A Gender-Specific Effect on Glucose Regulation

This study highlights the intriguing sex-specific effects of quinine on glucose regulation, emphasizing the importance of considering individual differences in drug responses. The findings suggest that women may experience greater glucose-lowering effects from quinine compared to men, even with similar gastrointestinal impacts. These insights are crucial for understanding the nuances of drug efficacy and tailoring treatment approaches based on individual patient characteristics.

Navigating the Desert of Drug Response

The study's findings highlight the importance of considering gender-specific differences in drug responses. It serves as a reminder that the desert of pharmacology is full of complex interactions, and the effects of medications can vary significantly between individuals. Understanding these differences can lead to more personalized and effective treatments.

Dr.Camel's Conclusion

This study's discovery of quinine's gender-specific effects on glucose regulation sheds light on the intricate dance between medication and our bodies. It reinforces the importance of considering individual characteristics, including gender, when designing and administering drug treatments, as the desert of pharmacology is full of surprises.
Date :
  1. Date Completed 2023-08-28
  2. Date Revised 2023-08-29
Further Info :

Pubmed ID

37630774

DOI: Digital Object Identifier

PMC10459881

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Article Analysis
・Effects of quinine
SNS
PICO Info
in preparation
Languages

English

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