VOGT-KOYANAGI-HARADA DISEASE-LIKE UVEITIS IN A PATIENT WITH ADVANCED MELANOMA TREATED BY SEQUENTIAL ADMINISTRATION OF NIVOLUMAB AND DABRAFENIB/TRAMETINIB THERAPY.

Author: JacobJulie, MadoeAline, SchauwvlieghePieter-Paul

Paper Details 
Original Abstract of the Article :
To describe a case of bilateral Vogt-Koyanagi-Harada (VKH)-like uveitis during treatment with dabrafenib and trametinib and three months after discontinuation of nivolumab for malignant melanoma, and discuss the possible (synergistic) role(s) of mitogen-activated protein kinase (MAPK) inhibitors and...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/37643052

データ提供:米国国立医学図書館(NLM)

A Complex Case: VKH-Like Uveitis and Targeted Cancer Therapies

The realm of [ophthalmology] often faces complex and challenging cases. This case study highlights the potential for [Vogt-Koyanagi-Harada (VKH)-like uveitis], a rare inflammatory eye condition, to occur during treatment with [dabrafenib and trametinib], targeted therapies used for [melanoma]. The researchers present a case of a patient who developed this condition after receiving these medications.

This case study raises important questions about the potential link between these targeted therapies and [VKH-like uveitis]. Further research is needed to fully understand the potential risks associated with these medications and to develop strategies for managing this rare but potentially serious complication.

Unraveling the Connection: VKH-Like Uveitis and Targeted Therapies

This case study underscores the potential for [VKH-like uveitis] to develop during treatment with [dabrafenib and trametinib], targeted therapies for [melanoma]. This finding highlights the need for further research to understand the complex interplay between these medications and the immune system, potentially leading to new strategies for managing this rare but potentially serious side effect.

Monitoring for Complications: A Crucial Step in Cancer Treatment

This case study highlights the importance of careful monitoring for potential complications during treatment with [targeted therapies] for [melanoma]. The occurrence of [VKH-like uveitis] in this patient underscores the need for vigilant observation and prompt intervention if necessary.

Dr. Camel's Conclusion

This case study presents a complex and intriguing case of [VKH-like uveitis] developing during treatment with [dabrafenib and trametinib], targeted therapies for [melanoma]. The findings emphasize the importance of careful monitoring for potential complications and further research to understand the complex interactions between these medications and the immune system.

Date :
  1. Date Completed 2023-08-31
  2. Date Revised 2023-08-31
Further Info :

Pubmed ID

37643052

DOI: Digital Object Identifier

01271216-202309000-00027

Related Literature

SNS
PICO Info
in preparation
Languages

English

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