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Cognitive effect of antiseizure medications in medial temporal lobe epilepsy.

Author: DenosMarisa, DupontSophie, DusanterCedric, HerlinBastien, HouotMarion, MereMarie, NavarroVincent, SamsonSéverine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Anti-seizure medications (ASMs) have a significant impact on cognition, especially in patients with medial temporal lobe epilepsy associated with hippocampal sclerosis. This retrospective study of 287 patients found that the total number of ASMs and specific medications, particularly topiramate (TPM) and sodium valproate (VPA), were key factors affecting cognition. TPM and VPA were associated with an overall detrimental effect on cognition, while other ASMs had specific cognitive effects. Non-modifiable factors like age at testing, seizure onset, and history of febrile seizures also influenced cognition.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND PURPOSE: The specific effects of antiseizure medications (ASMs) on cognition are a rich field of study, with many ongoing questions. The aim of this study was to evaluate these effects in a homogeneous group of patients with epilepsy to guide clinicians to choose the most appropriate ...See full text at original site
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引用元：
https://doi.org/10.1111/ene.16050

データ提供：米国国立医学図書館（NLM）

Navigating the Cognitive Landscape of Epilepsy Medication

The quest for effective treatments for epilepsy is like navigating a complex and often challenging desert, filled with potential pitfalls. This research explores the impact of antiseizure medications (ASMs) on cognition in patients with medial temporal lobe epilepsy. Understanding the cognitive effects of ASMs is crucial for optimizing treatment strategies and minimizing potential side effects. The authors aimed to identify cognitive profiles associated with different ASMs, providing valuable insights for clinicians seeking to choose the most appropriate medications for their patients.

Cognitive Effects of Antiseizure Medications in Medial Temporal Lobe Epilepsy

Imagine a desert oasis where each well represents a different cognitive function. This study delves into the effects of ASMs on these cognitive wells, revealing that certain medications can have a significant impact on specific cognitive areas. The research identified four distinct cognitive profiles associated with different ASMs, providing clinicians with valuable information to tailor treatment strategies and optimize cognitive outcomes.

Finding the Right Path in Epilepsy Management

Navigating the complex landscape of epilepsy management requires careful consideration of the cognitive effects of ASMs. This study provides clinicians with a roadmap to help them choose the most appropriate medications for their patients, minimizing potential cognitive side effects and maximizing cognitive function. The authors' findings emphasize the importance of personalized treatment approaches, taking into account the unique cognitive needs of each patient.

Dr.Camel's Conclusion

The treatment of epilepsy requires navigating a complex desert of medication options, each with its own cognitive landscape. This study acts as a compass, guiding clinicians through this intricate terrain by identifying cognitive profiles associated with different ASMs. The research highlights the importance of understanding the cognitive effects of these medications, allowing for personalized treatment approaches and maximizing the well-being of patients with epilepsy.

Date :
  1. Date Completed 2023-11-10
  2. Date Revised 2023-11-14
Further Info :

Pubmed ID

37650365

DOI: Digital Object Identifier

10.1111/ene.16050

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English

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