Dual nanocarrier of chlorhexidine and fluconazole: Physicochemical characterization and effects on microcosm biofilms and oral keratinocytes.

Author: AraujoHeitor Ceolin, CaldeirãoAnne Caroline Morais, ConstantinoCarlos José Leopoldo, DelbemAlberto Carlos Botazzo, MonteiroDouglas Roberto, OliveiraMarcelo José Dos Santos, OliveiraSandra Helena Penha, PessanJuliano Pelim, RamageGordon, SalesDouglas Henrique, SampaioCaio, TeixeiraSilvio Rainho

Paper Details 
Original Abstract of the Article :
OBJECTIVES: This study assembled and characterized a dual nanocarrier of chlorhexidine (CHX) and fluconazole (FLZ), and evaluated its antibiofilm and cytotoxic effects. METHODS: CHX and FLZ were added to iron oxide nanoparticles (IONPs) previously coated by chitosan (CS) and characterized by physic...See full text at original site
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引用元:
https://doi.org/10.1016/j.jdent.2023.104699

データ提供:米国国立医学図書館(NLM)

Dual Nanocarrier for Oral Candidiasis: A New Oasis in the Desert of Oral Infections

Oral candidiasis, a common fungal infection of the mouth, is like a desert wind that can cause discomfort and irritation. This study explores the potential of a dual nanocarrier, a tiny vehicle designed to deliver medication directly to the site of infection, to combat this stubborn foe.

The researchers developed a dual nanocarrier containing chlorhexidine and fluconazole, two antifungal medications. The study evaluated the nanocarrier's effectiveness against biofilms, those sticky communities of bacteria and fungi that often contribute to infections. The authors' findings suggest that the nanocarrier could be a promising approach for treating oral candidiasis, offering a targeted delivery system that effectively reduces the growth of both bacteria and fungi. The authors also found that the nanocarrier had a lower cytotoxic effect on oral keratinocytes (cells found in the mouth) compared to the same concentrations of the individual drugs.

A Targeted Approach: Fighting Infections with Precision

The study's findings offer a promising new avenue for treating oral candidiasis. The researchers' work suggests that a dual nanocarrier could be an effective way to deliver antifungal medications directly to the site of infection. This approach, like a camel navigating a desert oasis, targets the source of the infection, potentially reducing the risk of side effects and improving treatment outcomes.

A New Frontier in Oral Health: Exploring the Oasis of Nanotherapy

This study highlights the exciting possibilities of nanotechnology for treating oral infections. The authors' work suggests that nanocarriers could be a valuable tool for delivering medication directly to the site of infection, potentially improving treatment effectiveness and minimizing side effects. The study's findings encourage further research into the potential of nanotherapy for a range of oral health conditions.

Dr. Camel's Conclusion

This research is a testament to the innovative spirit of scientific exploration. The study's findings suggest that a dual nanocarrier could be a powerful weapon against oral candidiasis, offering a targeted and potentially more effective approach to treatment. The authors' work highlights the potential of nanotechnology to transform the landscape of oral health, paving the way for new and effective treatments for a range of conditions.

Date :
  1. Date Completed 2023-10-30
  2. Date Revised 2023-10-30
Further Info :

Pubmed ID

37716636

DOI: Digital Object Identifier

10.1016/j.jdent.2023.104699

Related Literature

SNS
PICO Info
in preparation
Languages

English

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