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Molecular characterization and differential effects of levofloxacin and ciprofloxacin on the potential for developing quinolone resistance among clinical <i>Pseudomonas aeruginosa</i> isolates.
Author: Abou FayadAntoine G, AlGhoribiMajed F, ArajGeorge F, DoumatGeorge, DoumithMichel, El HafiBassam, FremJim Abi, GharamtiAmal, KanafaniZeina A, KanjSouha S, MatarGhassan M, SleimanAhmad
Original Abstract of the Article :
Label="Background" NlmCategory="UNASSIGNED">Fluoroquinolones are some of the most used antimicrobial agents for the treatment of <i>Pseudomonas aeruginosa</i>. This study aimed at exploring the differential activity of ciprofloxacin and levofloxacin on the selection of resistance among <i>P. aerugin...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514475/
データ提供：米国国立医学図書館（NLM）
Differential Effects of Levofloxacin and Ciprofloxacin on Quinolone Resistance in *Pseudomonas aeruginosa*
This study explores the differential effects of levofloxacin and ciprofloxacin, two fluoroquinolone antibiotics, on the development of quinolone resistance in *Pseudomonas aeruginosa*. The study aims to understand the mechanisms underlying the selection of resistance and to identify potential strategies for minimizing the emergence of resistant strains.
Differential Effects of Fluoroquinolones on Resistance Selection
The study found that levofloxacin and ciprofloxacin exhibited different activities in selecting for quinolone resistance in *Pseudomonas aeruginosa*. The findings suggest that levofloxacin may be more prone to selecting for resistant strains compared to ciprofloxacin. This information could be valuable for optimizing antibiotic selection and minimizing the risk of developing resistance.
Implications for Antimicrobial Stewardship
The findings of this study have important implications for antimicrobial stewardship. It highlights the need for careful antibiotic selection to minimize the development of resistance. Understanding the differential effects of different antibiotics on resistance selection is crucial for preventing the spread of resistant strains. It's like navigating a delicate desert ecosystem, where introducing the wrong species can disrupt the balance and lead to undesirable consequences.
Dr. Camel's Conclusion
This study investigates the differential effects of levofloxacin and ciprofloxacin on the development of quinolone resistance in *Pseudomonas aeruginosa*. The findings highlight the importance of understanding the mechanisms underlying resistance selection to optimize antibiotic stewardship and minimize the emergence of resistant strains. It's like navigating the complex desert landscape of antibiotic resistance, seeking to find strategies that preserve the effectiveness of these essential medications.
Date :
- Date Completed n.d.
- Date Revised 2023-09-26
Further Info :
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