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Adverse respiratory and cardiovascular events attributed to timolol ophthalmic solution, 1978-1985.

Author: ArrowsmithJ B, FraunfelderF T, KuritskyJ N, NelsonW L, SillsJ M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

A review of 450 case reports of serious respiratory and cardiovascular events attributed to ophthalmic timolol revealed that 55% of patients experienced a cardiac arrhythmia or a bronchospasm-related event. Most patients improved after discontinuing the drug.
Paper Details　
Original Abstract of the Article :
Between September 1978 and December 1985, 450 case reports of serious respiratory and cardiovascular events and 32 case reports of death attributed to ophthalmic timolol were received by the United States Food and Drug Administration and the National Registry of Drug-Induced Ocular Side Effects. Two...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9394(86)90532-5

データ提供：米国国立医学図書館（NLM）

Timolol Ophthalmic Solution: A Desert of Unexpected Side Effects

Timolol ophthalmic solution is a commonly used medication to treat glaucoma. However, like a desert landscape, this seemingly benign medication can hold hidden dangers. This research investigates the occurrence of serious respiratory and cardiovascular events attributed to timolol ophthalmic solution, highlighting the potential for unexpected side effects.

Navigating a Desert of Risks

This research reviews case reports of serious respiratory and cardiovascular events attributed to timolol ophthalmic solution. The researchers analyzed 450 case reports and 32 death reports from the United States Food and Drug Administration and the National Registry of Drug-Induced Ocular Side Effects. The study delves into the potential risks associated with timolol, akin to mapping out the dangers of a treacherous desert.

Unexpected Challenges

The study found a significant number of patients experiencing cardiac arrhythmias and bronchospasm-related events after using timolol. This is like encountering a sandstorm or a hidden canyon in the desert, a seemingly safe landscape suddenly turning hazardous. The findings emphasize the importance of careful monitoring and awareness of potential risks associated with medications, even those intended for specific localized treatments.

Dr. Camel's Conclusion

This research serves as a reminder that even seemingly safe medications can have unexpected side effects. It underscores the importance of vigilance and patient monitoring, particularly in individuals with pre-existing conditions. Just as a traveler must be prepared for the unexpected dangers of the desert, healthcare providers need to be aware of the potential risks associated with medications.
Date :
  1. Date Completed 1986-12-04
  2. Date Revised 2019-06-27
Further Info :

Pubmed ID

3777080

DOI: Digital Object Identifier

10.1016/0002-9394(86)90532-5

Related Literature

Article Analysis
・Side Effects of timolol ophthalmic
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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