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Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism.

Author: BarchanskaHanna, Kostina-BednarzMarianna, PłonkaJoanna

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of amantadine and rimantadine, two drugs used to treat Parkinson's disease, on metabolism in yeast. Resveratrol supplementation was found to increase the metabolism of rimantadine, potentially reducing side effects.
Paper Details　
Original Abstract of the Article :
Metabolic profiling offers huge potential to highlight markers and mechanisms in support of toxicology and pathology investigations during drug development. The main objective was to modify therapy with adamantane derivatives: amantadine and rimantadine, to increase their bioavailability and evaluat...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555991/

データ提供：米国国立医学図書館（NLM）

Metabolic Profiling: Unlocking the Secrets of Amantadine and Rimantadine

Drug development is a complex and intricate process, akin to navigating a vast desert landscape. This study delves into the world of metabolic profiling, a powerful tool for understanding the impact of drugs on biological systems. The researchers employ this approach to investigate the effects of amantadine and rimantadine, antiviral medications used to treat influenza, on a model organism.

The researchers used Saccharomyces cerevisiae, a model organism known for its ease of manipulation and relevance to human biology, to study the effects of amantadine and rimantadine. They discovered that resveratrol supplementation synergistically enhanced the effects of amantadine and altered the metabolism of rimantadine, potentially reducing side effects. Their findings provide valuable insights into the complex interactions between drugs, metabolites, and cellular processes.

Unveiling the Nuances of Drug Metabolism and Toxicity

This study demonstrates the potential of metabolic profiling to unlock hidden secrets of drug efficacy and toxicity. The researchers' findings highlight the importance of considering individual variations in drug metabolism and the potential for using dietary supplements to enhance treatment outcomes. This research provides a valuable tool for optimizing drug development and improving patient care.

Dr. Camel's Conclusion

This study reminds us that the desert of drug development is filled with hidden treasures waiting to be discovered. The researchers' innovative use of metabolic profiling opens up new avenues for understanding the intricate relationships between drugs, metabolism, and health outcomes. As researchers, we must continue to explore these complex relationships to develop safer and more effective therapies for patients.

Date :
  1. Date Completed 2023-11-02
  2. Date Revised 2023-11-21
Further Info :

Pubmed ID

37798340

DOI: Digital Object Identifier

PMC10555991

SNS
PICO Info
in preparation
Languages

English

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